Observational studyJournal of perinatology : official journal of the California Perinatal Association2021
Early assessment of lung aeration using an ultrasound score as a biomarker of developing bronchopulmonary dysplasia: a prospective observational study.
Observational study in Journal of perinatology : official journal of the California Perinatal Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Safety of the Intratracheal Administration of Budesonide With Porcine Pulmonary Surfactant in Very Preterm Infants to Prevent Bronchopulmonary Dysplasia: Randomized Clinical Trial (BuS Trial)
Lung Ultrasound Score (LUS) as Early Predictor of Bronchopulmonary Dysplasia (BPD) in Preterm Newborns: A Prospective, Multicenter, Observational Study
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Diagnostic accuracy of lung ultrasound score for bronchopulmonary dysplasia in preterm neonates: a systematic review and meta-analysis.Frontiers in pediatrics · 2025Pooled it
- Trial
- Serial lung ultrasound scoring for predicting invasive mechanical ventilation in preterm neonates: a prospective diagnostic accuracy study.European journal of pediatrics · 2026Article
- Trajectory of lung ultrasound scores in preterm infants at risk for bronchopulmonary dysplasia.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Application of lung ultrasound focusing on posterior zones in prediction of bronchopulmonary dysplasia in preterm infants: a prospective cohort study.Journal of ultrasound · 2026Article
- Outpatient assessment of bronchopulmonary dysplasia using point of care lung ultrasound.Frontiers in pediatrics · 2026Article
- Article
- Point-of-care lung ultrasound for continuous positive airway pressure discontinuation in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Lung ultrasound in early prediction of bronchopulmonary dysplasia in pre-term babies.Journal of ultrasound · 2024Article
- Proportion of confluent B-Lines predicts respiratory support in term infants shortly after birth.Respiratory research · 2024Observational
- Prognostic Relevance of the Lung Ultrasound Score: A Multioutcome Study in Infants with Respiratory Distress Syndrome.American journal of perinatology · 2024Article
- Lung ultrasound score as a tool to predict severity of bronchopulmonary dysplasia in neonates born ≤25 weeks of gestational age.Journal of perinatology : official journal of the California Perinatal Association · 2024Observational
- The Predictive Value of Lung Ultrasound Score on Hemodynamically Significant Patent Ductus Arteriosus among Neonates ≤25 Weeks.Diagnostics (Basel, Switzerland) · 2023Article
- Neonatal cardiorespiratory imaging-a multimodality state-of-the-art review.Pediatric radiology · 2023Article
- Prediction of respiratory distress severity and bronchopulmonary dysplasia by lung ultrasounds and transthoracic electrical bioimpedance.European journal of pediatrics · 2023Observational
- Use of Cardio-Pulmonary Ultrasound in the Neonatal Intensive Care Unit.Children (Basel, Switzerland) · 2023Review
- A scoping review of echocardiographic and lung ultrasound biomarkers of bronchopulmonary dysplasia in preterm infants.Frontiers in pediatrics · 2023Article
- Lung ultrasound score has better diagnostic ability than NT-proBNP to predict moderate-severe bronchopulmonary dysplasia.European journal of pediatrics · 2022Article
- Role of Disease Progression Models in Drug Development.Pharmaceutical research · 2022Review
- A modified lung ultrasound score to evaluate short-term clinical outcomes of bronchopulmonary dysplasia.BMC pulmonary medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to assess the predictive value of a lung ultrasound (LUS) score in the development of moderate-severe bronchopulmonary dysplasia (sBPD). This was a prospective observational diagnostic accuracy study in a third-level neonatal intensive care unit. Preterm infants with a gestational age below 32 weeks were included. A LUS score (range 0-24 points) was calculated by assessing aeration semiquantitatively (0-3 points) in eight lung zones on the 7th day of life (DOL) and repeated on the 28th DOL. ROC curves and logistic regression were used for analysis. Forty-two preterm infants were included. The LUS on the 7th DOL had an area under the receiver operating characteristic curve (AUROC) of 0.94 (95% CI: 0.87-1) for the prediction of sBPD (optimal cutoff of ≥8 points: sensitivity 93%, specificity 91%). The LUS score was independently associated with sBPD [OR 2.1 (95% CI: 1.1-3.9), p = 0.022, for each additional point in the score]. Conclusions: Lung aeration as assessed by LUS on the 7th DOL may predict the development of sBPD.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.