SynthesisBMJ open gastroenterology2020
Correlation between gastrointestinal symptoms and disease severity in patients with COVID-19: a systematic review and meta-analysis.
Synthesis in BMJ open gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Nirmatrelvir/ritonavir or Molnupiravir for treatment of non-hospitalized patients with COVID-19 at risk of disease progression.PloS one · 2024Article
- Gut as an Alternative Entry Route for SARS-CoV-2: Current Evidence and Uncertainties of Productive Enteric Infection in COVID-19.Journal of clinical medicine · 2022Review
- Clinical presentation of COVID-19 in patients with inflammatory bowel disease: a systematic review and meta-analysis.Intestinal research · 2022Article
- Acute Gastrointestinal Injury and Feeding Intolerance as Prognostic Factors in Critically Ill COVID-19 Patients.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022Article
- Digestive system involvement and clinical outcomes among COVID-19 patients: A retrospective cohort study from Qatar.World journal of gastroenterology · 2021Article
- Mortality is not increased in SARS-CoV-2 infected persons with hepatitis C virus infection.Liver international : official journal of the International Association for the Study of the Liver · 2021Article
- Autoimmunity and COVID-19 - The microbiotal connection.Autoimmunity reviews · 2021Review
- Potential intestinal infection and faecal-oral transmission of SARS-CoV-2.Nature reviews. Gastroenterology & hepatology · 2021Review
- Pathogenesis and Mechanism of Gastrointestinal Infection With COVID-19.Frontiers in immunology · 2021Review
- Rates and characteristics of SARS-CoV-2 infection in persons with hepatitis C virus infection.Liver international : official journal of the International Association for the Study of the Liver · 2021Article
- Association between severity of COVID-19 symptoms and habitual food intake in adult outpatients.BMJ nutrition, prevention & health · 2021Article
- Article
- A COVID-19 Case Complicated byJournal of medical cases · 2020Article
- Gastrointestinal manifestations of COVID-19 in a single center in the Eastern Province of Saudi Arabia.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationObservational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the correlation between gastrointestinal (GI) symptoms and disease severity in patients with COVID-19.
designWe searched six databases including three Chinese and three English databases for all the published articles on COVID-19. Studies were screened according to inclusion and exclusion criteria. The relevant data were extracted and all the statistical analyses were performed using Revman5.3.
resultIn a meta-analysis of 9 studies, comprising 3022 patients, 479 patients (13.7%, 95% CI 0.125 to 0.149) had severe disease and 624 patients (14.7%, 95% CI 0.136 to 0.159) had GI symptoms. Of 624 patients with GI symptoms, 118 patients had severe disease (20.5%, 95% CI 0.133 to 0.276) and of 2397 cases without GI symptoms, 361 patients had severe disease (18.2%, 95% CI 0.129 to 0.235). Comparing disease severity of patients with and without GI symptoms, the results indicated: I²=62%, OR=1.21, 95% CI 0.94 to 1.56, p=0.13; there was no statistically significant difference between the two groups. The funnel plot was symmetrical with no publication bias.
conclusionCurrent results are not sufficient to demonstrate a significant correlation between GI symptoms and disease severity in patients with COVID-19.
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