Observational studyBMJ open diabetes research & care2020
Renal hyperfiltration is independently associated with increased all-cause mortality in individuals with type 2 diabetes: a prospective cohort study.
Observational study in BMJ open diabetes research & care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00715481 (Reduced Estimated Glomerular Filtration Rate), which is not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reduced Estimated Glomerular Filtration Rate (eGFR)and Prediction of Cardiovascular Disease and Renal Outcome in Subjects With Type 2 Diabetes: Italian Multicenter Study
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Association of glomerular hyperfiltration with mortality in stroke: an analysis using pooled individual patient data.European stroke journal · 2026Pooled it
- Glomerular hyperfiltration defined by eGFR and long-term clinical outcomes: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Prognostic Value of Estimated Glomerular Filtration Rate in Older Patients With Acute Coronary Syndrome.Reviews in cardiovascular medicine · 2026Article
- Estimation of age and sex-specific Glomerular Filtration Rate and its association with mortality and atherosclerotic cardiovascular outcomes in the Abu Dhabi population; A Retrospective Cohort Study.Journal of nephrology · 2025Article
- Incidence and predictors of type 2 diabetes mellitus in a population-based cohort study in Abu Dhabi.Scientific reports · 2025Article
- Effect of Glomerular Hyperfiltration on Incident Cardiovascular Disease in Patients with Type 2 Diabetes Mellitus.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Association between frailty and bone health in early-stage chronic kidney disease: a study from the population-based CARTaGENE cohort.Clinical kidney journal · 2025Article
- Approaches to predict future type 2 diabetes mellitus and chronic kidney disease: A scoping review.PloS one · 2025Article
- A Cross-Sectional Study of Glomerular Hyperfiltration in Polycystic Ovary Syndrome.International journal of molecular sciences · 2024Article
- Heterogeneity by age and gender in the association of kidney function with mortality among patients with diabetes - analysis of diabetes registry in Singapore.BMC nephrology · 2024Article
- Kidney function predicts new-onset cardiorenal events and mortality in primary aldosteronism: approach of the 2021 race-free eGFR equation.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Observational
- Unveiling the Hidden Burden: Estimating All-Cause Mortality Risk in Older Individuals with Type 2 Diabetes.Journal of diabetes research · 2024Article
- The association between renal hyperfiltration and mortality is not mediated by diabetes mellitus.International urology and nephrology · 2023Article
- Genetics of diabetes-associated microvascular complications.Diabetologia · 2023Review
- Finerenone: Questions and Answers-The Four Fundamental Arguments on the New-Born Promising Non-Steroidal Mineralocorticoid Receptor Antagonist.Journal of clinical medicine · 2023Review
- Parameters influencing renal response to SGLT2 inhibitors and GLP1 receptor agonists in type 2 diabetes patients with preserved renal function: a comparative, prospective study.Journal of endocrinological investigation · 2023Article
- Sex-specific association of body mass index and fatty liver index with prevalence of renal hyperfiltration: a cross sectional study using Japanese health check-up data.BMC nephrology · 2023Article
- Glomerular Hyperfiltration Predicts Kidney Function Decline and Mortality in Type 1 and Type 2 Diabetes: A 21-Year Longitudinal Study.Diabetes care · 2023Article
- Impact of albuminuria on the various causes of death in diabetic patients: a nationwide population-based study.Scientific reports · 2023Article
- Mortality-based definition of renal hyperfiltration in middle-aged men: a 35-year cohort from Finland.International urology and nephrology · 2022Article
Corrections and comments
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Authors and funding
13 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIn addition to favoring renal disease progression, renal 'hyperfiltration' has been associated with an increased risk of death, though it is unclear whether and how excess mortality is related to increased renal function. We investigated whether renal hyperfiltration is an independent predictor of death in patients with type 2 diabetes from the Renal Insufficiency And Cardiovascular Events Italian multicenter study. RESEARCH DESIGN AND
methodsThis observational, prospective cohort study enrolled 15 773 patients with type 2 diabetes consecutively attending 19 Italian diabetes clinics in 2006-2008. Serum creatinine, albuminuria, cardiovascular risk factors, and complications/comorbidities were assessed at baseline. Vital status on 31 October 2015 was retrieved for 15 656 patients (99.26%). Patients were stratified (A) by absolute estimated glomerular filtration rate (eGFR) values in eGFR deciles or Kidney Disease: Improving Global Outcomes (KDIGO) categories and (B) based on age-corrected thresholds or age and gender-specific 95th and 5th percentiles in hyperfiltration, hypofiltration, and normofiltration groups.
resultsThe highest eGFR decile/category and the hyperfiltration group included (partly) different individuals with similar clinical features. Age and gender-adjusted death rates were significantly higher in deciles 1, 9, and 10 (≥103.9, 50.9-62.7, and <50.9 mL/min/1.73 m
conclusionsIn type 2 diabetes, both high-normal eGFR and hyperfiltration are associated with an increased risk of death from any cause, independent of confounders that may directly impact on mortality and/or affect GFR estimation. Further studies are required to clarify the nature of this relationship. TRIAL REGISTRATION NUMBER: NCT00715481.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.