Evidence map›Paper›PMID 32665276›Full record

ArticlemBio2020

Conditional DnaB Protein Splicing Is Reversibly Inhibited by Zinc in Mycobacteria.

Daniel Woods, Sweta Vangaveti, Ikechukwu Egbanum, Allison M Sweeney, Zhong Li, Valjean Bacot-Davis, Danielle S LeSassier, Matthew Stanger, Gabrielle E Hardison, Hongmin Li and 2 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. A Unique THN Motif Is Critical for Enabling Efficient C-Terminal Traceless Cleavage.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Conditional protein splicing of thebioRxiv : the preprint server for biology · 2024
    Article
  9. An intein-based biosensor to measure protein stability in vivo.Protein science : a publication of the Protein Society · 2024
    Article
  10. Article
  11. Review
  12. An artificially split class 3 intein.microPublication biology · 2023
    Article
  13. Review
  14. Calcimycin InhibitsACS infectious diseases · 2022
    Article
  15. Article
  16. Inteins as Drug Targets and Therapeutic Tools.Frontiers in molecular biosciences · 2022
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Daniel WoodsDepartment of Biological Sciences, University at Albany, Albany, New York, USA.
Sweta VangavetiThe RNA Institute, University at Albany, Albany, New York, USA.
Ikechukwu EgbanumDepartment of Biological Sciences, University at Albany, Albany, New York, USA.
Allison M SweeneyDepartment of Biology, Murray State University, Murray, Kentucky, USA.
Zhong LiWadsworth Center, New York State Department of Health, Albany, New York, USA.
Valjean Bacot-DavisRenaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.
Danielle S LeSassierSignature Science, LLC, Austin, Texas, USA.
Matthew StangerDepartment of Biological Sciences, University at Albany, Albany, New York, USA.
Gabrielle E HardisonDepartment of Biology, Murray State University, Murray, Kentucky, USA.
Hongmin LiDepartment of Biological Sciences, University at Albany, Albany, New York, USA.
Marlene BelfortDepartment of Biological Sciences, University at Albany, Albany, New York, USA mbelfort@albany.edu clennon1@murraystate.edu.
Christopher W LennonDepartment of Biology, Murray State University, Murray, Kentucky, USA mbelfort@albany.edu clennon1@murraystate.edu.
University at Albany, State University of New York · USMurray State University · USNew York State Department of Health · USSignature Research (United States) · USStony Brook School · US

Funding

WKU Lead Faculty AwardP20GM103436 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ERIC C ROUCHKA · 2012 to 2026
$60.1M
SELF-SPLICING INTEINS: FUNCTION, EVOLUTION, APPLICATIONR01GM044844 · NIGMS · WADSWORTH CENTER · PI BELFORT, MARLENE · 1990 to 2019
$8.9M
SELF-SPLICING INTRONS IN THE PHAGE T4/E COLI SYSTEMR01GM039422 · NIGMS · WADSWORTH CENTER · PI BELFORT, MARLENE · 1988 to 2019
$5.3M
INTRON DYNAMICS IN BACTERIAR37GM039422 · NIGMS · WADSWORTH CENTER · PI BELFORT, MARLENE · 2001 to 2010
$4.0M
High throughput screening of the Prp8 intein splicing inhibitors for pathogenic fungiR01AI140726 · NIAID · WADSWORTH CENTER · PI LI, HONGMIN · 2019 to 2022
$2.4M
Discovery of therapeutics against Cryptococcosis by Repurposing Pharmaceutical LibrariesR21AI141178 · NIAID · WADSWORTH CENTER · PI LI, HONGMIN · 2019 to 2020
$441k
Post-translational regulation of recombinase function by intein splicingF32GM121000 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI LENNON, CHRISTOPHER WILLIAM · 2016 to 2017
$119k
NIAID NIH HHS R01 AI140726NIAID NIH HHS R21 AI141178NIGMS NIH HHS F32 GM121000NIGMS NIH HHS P20 GM103436NIGMS NIH HHS R01 GM039422NIGMS NIH HHS R01 GM044844NIGMS NIH HHS R37 GM039422
6 · The paper itself

Abstract

Inteins, as posttranslational regulatory elements, can tune protein function to environmental changes by conditional protein splicing (CPS). Translated as subdomains interrupting host proteins, inteins splice to scarlessly join flanking sequences (exteins). We used DnaB-intein1 (DnaBi1) from a replicative helicase of

Indexed as

Bacterial ProteinsDnaB HelicasesEscherichia coliInteinsMycobacteriumProtein Processing, Post-TranslationalProtein SplicingZincBacterial ProteinsDnaB HelicasesZincconditional protein splicingDNA helicaseinteinmycobacteria

Identifiers

PMID32665276
PMCPMC7360933
OpenAlexW3042500722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.