ArticleEpidemiology and psychiatric sciences2020
Bidirectional association between blood pressure and depressive symptoms in young and middle-age adults: A cohort study.
Article in Epidemiology and psychiatric sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The relationship between renin-angiotensin system-modulating medication and depression: a systematic review.Translational psychiatry · 2026Pooled it
- Article
- Multidimensional sleep health and resting blood pressure in young adults: the role of negative affect.Journal of behavioral medicine · 2026Article
- Discovery of Personalized Treatment for Immuno-Metabolic Depression-Focus on 11beta Hydroxysteroid Dehydrogenase Type 2 (11betaHSD2) and Toll-like Receptor 4 (TLR4) Inhibition with Enoxolone.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Prospective association between depressive symptoms and incident hypertension: Results from the Hispanic community health study/study of Latinos.Journal of affective disorders · 2025Article
- Additional Non-Pharmacological Intervention for Elderly Patients With Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Exploring the Causal Relationships and Mediating Factors Between Mental Disorders and Hypertension: A Multivariable Mendelian Randomization Study.Global heart · 2025Article
- Prevalence and correlates of common mental disorders among participants of the Uganda Genome Resource: Opportunities for psychiatric genetics research.Molecular psychiatry · 2025Article
- Diabetes Is Positively Associated With High Risk of Depression in Korean Cervical Cancer Patients: Korean National Health and Nutrition Examination Survey 2010-2021.Psychiatry investigation · 2025Article
- Depressive symptoms as risk factors for the onset of home hypertension: a prospective cohort study.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Associations between daytime napping, sleep duration, and depression and 15 cardiovascular diseases: a Mendelian randomization study.Cardiovascular diagnosis and therapy · 2024Article
- Development and validation of the risk score for estimating suicide attempt in patients with major depressive disorder.Social psychiatry and psychiatric epidemiology · 2024Article
- Depressive symptoms are not associated with clinically important levels of digital home blood pressure in the electronic Framingham Heart Study.Cardiovascular digital health journal · 2024Article
- Association of diastolic and systolic blood pressure with depression: a cross-sectional study from NHANES 2005-2018.Frontiers in psychiatry · 2024Article
- Unveiling the Nexus: Depressive Symptoms and Medication Adherence in Hypertensive Patients' Self-care: A Systematic Review.Materia socio-medica · 2024Review
- Factors Associated with Symptoms of Depression among People with Obesity: Analysis of a 3-Year-Peruvian National Survey.International journal of environmental research and public health · 2023Article
- Bidirectional Association Between Probable Depression and Multimorbidity Among Middle-Aged and Older Adults in Thailand.Journal of multidisciplinary healthcare · 2023Article
- Mental distress along the cascade of care in managing hypertension.Scientific reports · 2022Article
- Development and validation using NHANES data of a predictive model for depression risk in myocardial infarction survivors.Heliyon · 2022Article
- Relevance of Objective Measures in Psychiatric Disorders-Rest-Activity Rhythm and Psychophysiological Measures.Current psychiatry reports · 2021Review
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo evaluate the bidirectional relationship between blood pressure (BP) and depressive symptoms using a large prospective cohort study.
methodsProspective cohort study was performed in 276 244 adults who participated in a regular health check-up and were followed annually or biennially for up to 5.9 years. BP levels were categorised according to the 2017 American College of Cardiology and American Heart Association hypertension guidelines. Depressive symptoms were assessed using Centre for Epidemiologic Studies-Depression (CESD) questionnaire and a cut-off score of ≥25 was regarded as case-level depressive symptoms.
resultsDuring 672 603.3 person-years of follow-up, 5222 participants developed case-level depressive symptoms. The multivariable-adjusted hazard ratios (HRs) [95% confidence interval (CI)] for incident case-level depressive symptoms comparing hypotension, elevated BP, hypertension stage 1 and hypertension stage 2 to normal BP were 1.07 (0.99-1.16), 0.93 (0.82-1.05), 0.89 (0.81-0.97) and 0.81 (0.62-1.06), respectively (p for trend <0.001). During 583 615.3 person-years of follow-up, 27 787 participants developed hypertension. The multivariable-adjusted HRs (95% CI) for incident hypertension comparing CESD 16-24 and ⩾25 to CESD < 16 were 1.05 (1.01-1.11) and 1.12 (1.03-1.20), respectively (p for trend <0.001) and in the time-dependent models, corresponding HRs (95% CI) were 1.12 (1.02-1.24) and 1.29 (1.10-1.50), respectively (p for trend <0.001).
conclusionsIn this large cohort study of young and middle-aged individuals, higher BP levels were independently associated with a decreased risk for developing case-level depressive symptoms and depressive symptoms were also associated with incident hypertension. Further studies are required to elucidate the mechanisms underlying the bidirectional association between BP levels and incident depression.
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