SynthesisThe Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques2021
Neurological Manifestations in COVID-19 Infection: A Systematic Review and Meta-Analysis.
Synthesis in The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 9 of them syntheses that pooled it.
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Who cites it
86 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Post-COVID-19 Vaccination Meningitis and Meningoencephalitis: A Systematic Review of Case Series and Case Reports.The American journal of tropical medicine and hygiene · 2025Pooled it
- Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) following COVID-19 vaccines: A systematic review.Revue neurologique · 2023Pooled it
- Late neurological consequences of SARS-CoV-2 infection: New challenges for the neurologist.Frontiers in neuroscience · 2023Pooled it
- Watch out for neuromyelitis optica spectrum disorder onset or clinical relapse after COVID-19 vaccination: What neurologists need to know?Multiple sclerosis and related disorders · 2022Pooled it
- Acute Disseminated Encephalomyelitis and Acute Hemorrhagic Leukoencephalitis Following COVID-19: Systematic Review and Meta-synthesis.Neurology(R) neuroimmunology & neuroinflammation · 2021Pooled it
- Neuroimaging Findings in Patients with COVID-19: A Systematic Review and Meta-Analysis.Korean journal of radiology · 2021Pooled it
- Neuropathologic findings of patients with COVID-19: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Pooled it
- COVID-19 in People Living with HIV: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Pooled it
- Real world research on transcranial magnetic stimulation treatment strategies for neuropsychiatric symptoms with long-COVID in Japan.Asian journal of psychiatry · 2023Trial
- Incidence of Neurological Manifestations in Critically Ill COVID-19 Patients: A Low-Resource Setting Experience.Cureus · 2025Article
- Significance of Neurological Manifestations and Their Association With Clinical Outcomes in Hospitalized COVID-19 Patients in Bandar Abbas, Iran: A Cross-Sectional Study.Health science reports · 2025Article
- Glial activation among individuals with neurological post-acute sequelae of coronavirus disease 2019: A positron emission tomography study of brain fog using [Brain, behavior, & immunity - health · 2025Article
- Differences in functional outcome of COVID-19 and non-COVID-19 patients with critical illness polyneuropathy/ myopathy: a multicenter cohort study.Journal of neurology · 2025Observational
- Multicentre case-control study on the association between COVID-19 vaccines and neurological disorders (COVIVAX).Scientific reports · 2025Article
- Review
- Persistent headache and chronic daily headache after COVID-19: a prospective cohort study.The Korean journal of pain · 2024Article
- Review
- Clinical outcomes of patients with seizure admitted for COVID-19: Findings from the Philippine CORONA study.Heliyon · 2024Article
- Does coronavirus disease 2019 affect peripheral and central auditory systems? Matched group cross-sectional study and six-month follow up.The Journal of laryngology and otology · 2024Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGrowing evidence showed that coronavirus disease 2019 (COVID-19) infection may present with neurological manifestations. This review aimed to determine the neurological manifestations and complications in COVID-19.
methodsWe conducted a systematic review and meta-analysis that included cohort and case series/reports involving a population of patients confirmed with COVID-19 infection and their neurologic manifestations. We searched the following electronic databases until April 18, 2020: PubMed, Embase, Scopus, and World Health Organization database (PROSPERO registration number: CRD42020180658).
resultsFrom 403 articles identified, 49 studies involving a total of 6,335 confirmed COVID-19 cases were included. The random-effects modeling analysis for each neurological symptom showed the following proportional point estimates with 95% confidence intervals: "headache" (0.12; 0.10-0.14; I2 = 77%), "dizziness" (0.08; 0.05-0.12; I2 = 82%), "headache and dizziness" (0.09; 0.06-0.13; I2 = 0%), "nausea" (0.07; 0.04-0.11; I2 = 79%), "vomiting" (0.05; 0.03-0.08; I2 = 74%), "nausea and vomiting" (0.06; 0.03-0.11; I2 = 83%), "confusion" (0.05; 0.02-0.14; I2 = 86%), and "myalgia" (0.21; 0.18-0.25; I2 = 85%). The most common neurological complication associated with COVID-19 infection was vascular disorders (n = 23); other associated conditions were encephalopathy (n = 3), encephalitis (n = 1), oculomotor nerve palsy (n = 1), isolated sudden-onset anosmia (n = 1), Guillain-Barré syndrome (n = 1), and Miller-Fisher syndrome (n = 2). Most patients with neurological complications survived (n = 14); a considerable number of patients died (n = 7); and the rest had unclear outcomes (n = 12).
conclusionThis review revealed that neurologic involvement may manifest in COVID-19 infection. What has initially been thought of as a primarily respiratory illness has evolved into a wide-ranging multi-organ disease.
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