ArticleJournal of neuroengineering and rehabilitation2020
Chronic nerve health following implantation of femoral nerve cuff electrodes.
Article in Journal of neuroengineering and rehabilitation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01923662 (Exploiting Selective Recruitment to Prolong Standing After SCI), which is not on this map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exploiting Selective Recruitment to Prolong Standing After SCI
Who cites it
9 citing papers in PubMed.
- Trends in neuroprosthetic technologies to restore sensations.Biomedical engineering letters · 2026Review
- Bibliometric analysis of research on spinal cord injury and functional electrical stimulation: trends and frontiers.Spinal cord · 2026Article
- Sensory feedback for gait in transtibial amputees: a narrative review of technologies and clinical outcomes.Frontiers in bioengineering and biotechnology · 2025Review
- Electrical stimulation for the treatment of spinal cord injuries: A review of the cellular and molecular mechanisms that drive functional improvements.Frontiers in cellular neuroscience · 2023Review
- Selective Neural Electrical Stimulation of an Injured Facial Nerve Using Chronically Implanted Dual Cuff Electrodes.Brain sciences · 2022Article
- Wireless microelectrode arrays for selective and chronically stable peripheral nerve stimulation for hindlimb movement.Journal of neural engineering · 2021Article
- Selective neural stimulation methods improve cycling exercise performance after spinal cord injury: a case series.Journal of neuroengineering and rehabilitation · 2021Article
- Biomedical and Tissue Engineering Strategies to Control Foreign Body Reaction to Invasive Neural Electrodes.Frontiers in bioengineering and biotechnology · 2021Review
- Intraoperative Responses May Predict Chronic Performance of Composite Flat Interface Nerve Electrodes on Human Femoral Nerves.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundPeripheral nerve stimulation with implanted nerve cuff electrodes can restore standing, stepping and other functions to individuals with spinal cord injury (SCI). We performed the first study to evaluate the clinical electrodiagnostic changes due to electrode implantation acutely, chronic presence on the nerve peri- and post-operatively, and long-term delivery of electrical stimulation.
methodsA man with bilateral lower extremity paralysis secondary to cervical SCI sustained 5 years prior to enrollment received an implanted standing neuroprosthesis including composite flat interface nerve electrodes (C-FINEs) electrodes implanted around the proximal femoral nerves near the inguinal ligaments. Electromyography quantified neurophysiology preoperatively, intraoperatively, and through 1 year postoperatively. Stimulation charge thresholds, evoked knee extension moments, and weight distribution during standing quantified neuroprosthesis function over the same interval.
resultsFemoral compound motor unit action potentials increased 31% in amplitude and 34% in area while evoked knee extension moments increased significantly (p < 0.01) by 79% over 1 year of rehabilitation with standing and quadriceps exercises. Charge thresholds were low and stable, averaging 19.7 nC ± 6.2 (SEM). Changes in saphenous nerve action potentials and needle electromyography suggested minor nerve irritation perioperatively.
conclusionsThis is the first human trial reporting acute and chronic neurophysiologic changes due to application of and stimulation through nerve cuff electrodes. Electrodiagnostics indicated preserved nerve health with strengthened responses following stimulated exercise. Temporary electrodiagnostic changes suggest minor nerve irritation only intra- and peri-operatively, not continuing chronically nor impacting function. These outcomes follow implantation of a neuroprosthesis enabling standing and demonstrate the ability to safely implant electrodes on the proximal femoral nerve close to the inguinal ligament. We demonstrate the electrodiagnostic findings that can be expected from implanting nerve cuff electrodes and their time-course for resolution, potentially applicable to prostheses modulating other peripheral nerves and functions.
trial registrationClinicalTrials.gov NCT01923662 , retrospectively registered August 15, 2013.
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Registered trials
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