ArticleRespiratory research2020
Nasal microbiota dominated by Moraxella spp. is associated with respiratory health in the elderly population: a case control study.
Article in Respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Effects of urban airborne particulate matter exposure on the human upper respiratory tract microbiome: a systematic review.Respiratory research · 2025Pooled it
- Meta-analysis of the human upper respiratory tract microbiome reveals robust taxonomic associations with health and disease.BMC biology · 2024Pooled it
- Microbiota profiles in pre-school children with respiratory infections: Modifications induced by the oral bacterial lysate OM-85.Frontiers in cellular and infection microbiology · 2022Trial
- Microbiome modelling for post-mortem interval estimation across species and climates: swine analogues in a British summer and external validation in human donors from the USA.Scientific reports · 2026Article
- Respiratory Microbiome Remodeling in Aging: Implications for Immunosenescence and Therapeutic Intervention.Immune network · 2026Review
- Composition and dynamics of the adult nasal microbiome.Microbiome · 2026Article
- Carriage epidemiology of Moraxella catarrhalis in an all-age community cohort between 2016 and 2018.Access microbiology · 2026Article
- Impact of seasonal variation on the oral and nasopharyngeal microbiome in school-aged children: the school MicroBE initiative.mSystems · 2025Article
- Insights into the relationship between nasal bacterial composition and susceptibility to early-life respiratory disease: a pilot observational study.medRxiv : the preprint server for health sciences · 2025Article
- Intranasal Transplantation of Microbiota Derived from Parkinson's Disease Mice Induced Astrocyte Activation and Neurodegenerative Pathology from Nose to Brain.Brain sciences · 2025Article
- Meta-transcriptomics Reveals Dysbiosis of the Respiratory Microbiome in Older Adults with Long COVID.Research (Washington, D.C.) · 2025Article
- Oropharyngeal detection of specific gut-derived Enterobacterales is associated with increased respiratory infection risk in older adults.Frontiers in aging · 2025Article
- Oropharyngeal microbiome profiling and its association with age and heart failure in the elderly population from the northernmost province of China.Microbiology spectrum · 2024Article
- Association between Moraxella keratitis and advanced glycation end products.Scientific reports · 2024Article
- Article
- The upper respiratory tract microbiota of healthy adults is affected by Streptococcus pneumoniae carriage, smoking habits, and contact with children.Microbiome · 2023Article
- Late-Onset Bleb-Related Endophthalmitis Caused byAntibiotics (Basel, Switzerland) · 2023Article
- Winds of change a tale of: asthma and microbiome.Frontiers in microbiology · 2023Review
- Nasal Microbiota, Olfactory Health, Neurological Disorders and Aging-A Review.Microorganisms · 2022Review
- Seminal Microbiota of Idiopathic Infertile Patients and Its Relationship With Sperm DNA Integrity.Frontiers in cell and developmental biology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe elderly (≥65 years) are one of the populations most at risk for respiratory tract infections (RTIs). The aim of this study was to determine whether nasal and/or oropharyngeal microbiota profiles are associated with age and RTIs.
methodsNasal and oropharyngeal swabs of 152 controls and 152 patients with an RTI were included. The latter group consisted of 72 patients with an upper respiratory tract infection (URTI) and 80 with a lower respiratory tract infection (LRTI). Both nasal and oropharyngeal swabs were subjected to microbiota profiling using amplicon sequencing of the 16S rRNA gene. Moraxella species were determined using quantitative real-time PCR and culture.
resultsBased on the microbiota profiles of the controls and the patients with an RTI, eight nasal and nine oropharyngeal microbiota clusters were defined. Nasal microbiota dominated by either Moraxella catarrhalis or Moraxella nonliquefaciens was significantly more prevalent in elderly compared to mid-aged adults in the control group (p = 0.002). Dominance by M. catarrhalis/nonliquefaciens was significantly less prevalent in elderly with an LRTI (p = 0.001) compared to controls with similar age.
conclusionsNasal microbiota dominated by M. catarrhalis/nonliquefaciens is associated with respiratory health in the elderly population.
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