Evidence map›Paper›PMID 32664898›Full record

ReviewThe journal of headache and pain2020

Persistent post-traumatic headache: a migrainous loop or not? The preclinical evidence.

Silvia Benemei, Alejandro Labastida-Ramírez, Ekaterina Abramova, Nicoletta Brunelli, Edoardo Caronna, Paola Diana, Roman Gapeshin, Maxi Dana Hofacker, Ilaria Maestrini, Enrique Martínez Pías and 5 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The journal of headache and pain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 49 citations in OpenAlex.

  1. Hypersensitivity to BKThe journal of headache and pain · 2024
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  11. Models for Treating Post-traumatic Headache.Current pain and headache reports · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 12 institutions in 6 countries.

Silvia BenemeiHealth Sciences Department, University of Florence and Headache Centre, Careggi University Hospital, Florence, Italy.ORCID http://orcid.org/0000-0001-6316-430X
Alejandro Labastida-RamírezDivision of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands.
Ekaterina AbramovaPain Clinic Unit, Department of Anesthesiology, Pirogov City Clinical Hospital, Moscow, Russia.
Nicoletta BrunelliCampus Biomedico University, Rome, Italy.
Edoardo CaronnaNeurology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Paola DianaChild Neuropsychiatry Unit, Department of PROMISE, University of Palermo, Palermo, Italy.
Roman GapeshinDepartment of Neurology and Manual Medicine, Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg, Russia.
Maxi Dana HofackerDepartment of Neurology, Headache Centre, Charité Universitatsmedizin Berlin, Berlin, Germany.
Ilaria MaestriniDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Enrique Martínez PíasNeurology Department, Hospital Clínico Universitario of Valladolid, Valladolid, Spain.
Petr MikulenkaDepartment of Neurology, Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic.
Olga TikhonovaDepartment of neurology, Kazaryan Clinic of Epileptology and Neurology, Moscow, Russia.
Paolo MartellettiDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Antoinette MaassenVanDenBrinkDivision of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands. a.vanharen-maassenvandenbrink@erasmusmc.nl.
European Headache Federation School of Advanced Studies (EHF-SAS)
Erasmus MC · NLSapienza University of Rome · ITCharité - Universitätsmedizin Berlin · DECharles University · CZCity Clinical Hospital · RUFirst Pavlov State Medical University of St. Petersburg · RUHospital Clínico Universitario de Valladolid · ESSt.Petersburg V.M.Bekhterev Psychoneurological Research Institute · RUUniversità Campus Bio-Medico · ITUniversity of Florence · ITUniversity of Palermo · ITVall d'Hebron Hospital Universitari · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccording to the International Classification of Headache Disorders 3, post-traumatic headache (PTH) attributed to traumatic brain injury (TBI) is a secondary headache reported to have developed within 7 days from head injury, regaining consciousness following the head injury, or discontinuation of medication(s) impairing the ability to sense or report headache following the head injury. It is one of the most common secondary headache disorders, and it is defined as persistent when it lasts more than 3 months. MAIN BODY: Currently, due to the high prevalence of this disorder, several preclinical studies have been conducted using different animal models of mild TBI to reproduce conditions that engender PTH. Despite representing a simplification of a complex disorder and displaying different limitations concerning the human condition, animal models are still a mainstay to study in vivo the mechanisms of PTH and have provided valuable insight into the pathophysiology and possible treatment strategies. Different models reproduce different types of trauma and have been ideated in order to ensure maximal proximity to the human condition and optimal experimental reproducibility.

conclusionAt present, despite its high prevalence, PTH is not entirely understood, and the differential contribution of pathophysiological mechanisms, also observed in other conditions like migraine, has to be clarified. Although facing limitations, animal models are needed to improve understanding of PTH. The knowledge of currently available models is necessary to all researchers who want to investigate PTH and contribute to unravel its mechanisms.

Indexed as

Disease Models, AnimalAnimalsBrain ConcussionHumansMigraine DisordersPost-Traumatic HeadachePrevalenceReproducibility of ResultsAnimal modelsHeadacheMigrainePainTraumatic brain injury

Identifiers

PMID32664898
PMCPMC7362418
OpenAlexW3028454749

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.