ArticleClinical pediatrics2020
Incidence of Celiac Disease in Down Syndrome: A Longitudinal, Population-Based Birth Cohort Study.
Article in Clinical pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review of celiac disease recommendations for children with Down syndrome.Journal of pediatric gastroenterology and nutrition · 2026Pooled it
- Prevalence and incidence of physical health conditions in people with intellectual disability - a systematic review.PloS one · 2021Pooled it
- Endocrine and Digestive Disorders Arising in Childhood in Down Syndrome and Their Cross-Talk.Nutrients · 2026Review
- Caregivers' Perspectives on Medical Management and Its Helpfulness in Down Syndrome.American journal of medical genetics. Part A · 2026Article
- Unraveling the Complexity of Celiac Disease: A Narrative Review of Its Multisystem Nature.Medicina (Kaunas, Lithuania) · 2026Review
- Prevalence and impact of endocrinopathies on growth in pediatric down syndrome patients: A retrospective analysis.Saudi medical journal · 2025Article
- Features of Celiac Disease in children and adolescents with Down syndrome: a single-center experience of annual screening.Frontiers in pediatrics · 2025Article
- Diagnostic abnormalities, disease severity and immunotherapy responsiveness in individuals with Down syndrome regression disorder.Scientific reports · 2024Article
- Foetal gluten immunogenic peptides during pregnancy: a new determinant on the coeliac exposome.BMC medicine · 2024Article
- The Spectrum of Duodenal Histologic Findings in Patients With Trisomy 21: A Multicenter Study.Journal of pediatric gastroenterology and nutrition · 2023Article
- Immunotherapy Responsiveness and Risk of Relapse in Down Syndrome Regression Disorder.Research square · 2023Article
- Disorders of Gut-Brain Interaction in a National Cohort of Children With Down Syndrome.Journal of neurogastroenterology and motility · 2023Article
- Celiac Disease Genetics, Pathogenesis, and Standard Therapy for Japanese Patients.International journal of molecular sciences · 2023Review
- A Comprehensive Review of the Neurological Manifestations of Celiac Disease and Its Treatment.Diseases (Basel, Switzerland) · 2022Review
- Incidence of fractures in people with intellectual disabilities over the life course: a retrospective matched cohort study.EClinicalMedicine · 2022Article
- Subclinical Hypothyroidism as the Most Common Thyroid Dysfunction Status in Children With Down's Syndrome.Frontiers in endocrinology · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
American Academy of Pediatrics (AAP) guidelines for children with Down syndrome (DS) include assessment for celiac disease (CD), although data to support this recommendation have been inconsistent. We determined the incidence of CD among children with DS in a population-based birth cohort of children born from 1976 to 2000 in Olmsted County, Minnesota. Individuals with karyotype-confirmed DS and CD (using diagnosis codes, positive serology, and duodenal biopsies) were identified. The incidence of CD in DS was compared with the published incidence of CD for Olmsted County residents (17.4 [95% confidence interval = 15.2-19.6] per 100 000 person-years). Among 45 individuals with DS from the birth cohort, 3 (6.7%) were identified with positive celiac serology and confirmatory biopsies at ages 9, 12, and 23 years, for an incidence of 325 per 100 000 person-years. Thus, individuals with DS have more than 18 times the incidence rate of CD compared with the general population, supporting the AAP guidelines.
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