Evidence map›Paper›PMID 32664674›Full record

ArticleInternational journal of molecular sciences2020

Mice Lacking Connective Tissue Growth Factor in the Forebrain Exhibit Delayed Seizure Response, Reduced C-Fos Expression and Different Microglial Phenotype Following Acute PTZ Injection.

Pei-Fen Siow, Chih-Yu Tsao, Ho-Ching Chang, Chwen-Yu Chen, I-Shing Yu, Kuang-Yung Lee, Li-Jen Lee

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Elevated reactive aggression in forebrain-specificJournal of cell communication and signaling · 2024
    Article
  5. Article
  6. Is there room in epilepsy for the claustrum?Frontiers in systems biology · 2024
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Pei-Fen SiowGraduate Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei 10048, Taiwan.ORCID 0000-0003-2864-6324
Chih-Yu TsaoGraduate Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei 10048, Taiwan.
Ho-Ching ChangGraduate Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei 10048, Taiwan.
Chwen-Yu ChenDepartment of Neurology, Chang Gung Memorial Hospital, Keelung 20401, Taiwan.
I-Shing YuLaboratory Animal Center, College of Medicine, National Taiwan University, Taipei 10048, Taiwan.ORCID 0000-0002-2369-5816
Kuang-Yung LeeDepartment of Neurology, Chang Gung Memorial Hospital, Keelung 20401, Taiwan.
Li-Jen LeeGraduate Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei 10048, Taiwan.ORCID 0000-0001-9108-3654
National Taiwan University · TWChang Gung Memorial Hospital · TWChang Gung University · TW

Funding

Chang Gung Medical Research Grant CMRPG2H0211Ministry of Education, Taiwan 109L7837
6 · The paper itself

Abstract

Connective tissue growth factor (CTGF) plays important roles in the development and regeneration of the connective tissue, yet its function in the nervous system is still not clear. CTGF is expressed in some distinct regions of the brain, including the dorsal endopiriform nucleus (DEPN) which has been recognized as an epileptogenic zone. We generated a forebrain-specific

Indexed as

Genes, fosAnimalsAstrocytesCell CountClaustrumConnective Tissue Growth FactorConvulsantsGene Expression RegulationHippocampusMaleMiceMice, Inbred C57BLMice, KnockoutMicrogliaNerve Tissue ProteinsPentylenetetrazoleCCN2 protein, mouseConnective Tissue Growth FactorConvulsantsNerve Tissue ProteinsPentylenetetrazoleProto-Oncogene Proteins c-fosendopiriform nucleusgene knockout micehippocampusneuronal activityPTZ-induced seizure

Identifiers

PMID32664674
PMCPMC7404259
OpenAlexW3041293308

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.