Evidence map›Paper›PMID 32664592›Full record

ArticleLife (Basel, Switzerland)2020

Embelin as Lead Compound for New Neuroserpin Polymerization Inhibitors.

Cristina Visentin, Loana Musso, Luca Broggini, Francesca Bonato, Rosaria Russo, Claudia Moriconi, Martino Bolognesi, Elena Miranda, Sabrina Dallavalle, Daniele Passarella and 1 more

Open access · goldAbstract read
In one paragraph

Article in Life (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Editing out the polymers: Toward a gene therapy for FENIB.Molecular therapy. Nucleic acids · 2025
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Neuroserpin: structure, function, physiology and pathology.Cellular and molecular life sciences : CMLS · 2021
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Cristina VisentinDipartimento di Bioscienze, Università degli Studi di Milano, Via Celoria, 26, 20133 Milan, Italy.
Loana MussoDipartimento di Scienze per gli Alimenti, la Nutrizione e l'Ambiente, Università degli Studi di Milano, Via Celoria, 2, 20133 Milan, Italy.
Luca BrogginiDipartimento di Bioscienze, Università degli Studi di Milano, Via Celoria, 26, 20133 Milan, Italy.ORCID 0000-0001-9472-6854
Francesca BonatoDipartimento di Chimica, Università degli Studi di Milano, Via Golgi, 19, 20133 Milan, Italy.
Rosaria RussoDipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Via Fratelli Cervi, 93, 20090 Segrate, Italy.ORCID 0000-0003-0011-5775
Claudia MoriconiDipartimento di Biologia e Biotecnologie 'Charles Darwin', Sapienza Università di Roma, Piazzale Aldo Moro, 5, 00185 Rome, Italy.
Martino BolognesiDipartimento di Bioscienze, Università degli Studi di Milano, Via Celoria, 26, 20133 Milan, Italy.ORCID 0000-0002-9253-5170
Elena MirandaDipartimento di Biologia e Biotecnologie 'Charles Darwin', Sapienza Università di Roma, Piazzale Aldo Moro, 5, 00185 Rome, Italy.ORCID 0000-0002-0586-8795
Sabrina DallavalleDipartimento di Scienze per gli Alimenti, la Nutrizione e l'Ambiente, Università degli Studi di Milano, Via Celoria, 2, 20133 Milan, Italy.ORCID 0000-0002-8813-8922
Daniele PassarellaDipartimento di Chimica, Università degli Studi di Milano, Via Golgi, 19, 20133 Milan, Italy.ORCID 0000-0001-6180-9581
Stefano RicagnoDipartimento di Bioscienze, Università degli Studi di Milano, Via Celoria, 26, 20133 Milan, Italy.ORCID 0000-0001-6678-5873
University of Milan · ITIstituto Pasteur · ITSapienza University of Rome · IT

Funding

Fondazione Telethon GGP1736
6 · The paper itself

Abstract

Familial encephalopathy with neuroserpin inclusion bodies (FENIB) is a severe and lethal neurodegenerative disease. Upon specific point mutations in the

Indexed as

drug designneurodegenerationprotein polymerization

Identifiers

PMID32664592
PMCPMC7400170
OpenAlexW3042124713

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.