Evidence map›Paper›PMID 32664473›Full record

ArticleInternational journal of molecular sciences2020

Molecular Characterization of a Novel Lytic Enzyme LysC from

Magdalena Plotka, Monika Szadkowska, Maria Håkansson, Rebeka Kovačič, Salam Al-Karadaghi, Björn Walse, Olesia Werbowy, Anna-Karina Kaczorowska, Tadeusz Kaczorowski

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
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  5. Creation of New Antimicrobial Peptides.International journal of molecular sciences · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. The Antibacterial Effect of PEGylated Carbosilane Dendrimers onInternational journal of molecular sciences · 2022
    Article
  11. Article
  12. Novel Lytic Enzyme of Prophage Origin fromInternational journal of molecular sciences · 2021
    Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Magdalena PlotkaLaboratory of Extremophiles Biology, Department of Microbiology, Faculty of Biology, University of Gdansk, 80-822 Gdansk, Poland.
Monika SzadkowskaLaboratory of Extremophiles Biology, Department of Microbiology, Faculty of Biology, University of Gdansk, 80-822 Gdansk, Poland.
Maria HåkanssonSARomics Biostructures, SE-223 81 Lund, Sweden.
Rebeka KovačičSARomics Biostructures, SE-223 81 Lund, Sweden.
Salam Al-KaradaghiSARomics Biostructures, SE-223 81 Lund, Sweden.
Björn WalseSARomics Biostructures, SE-223 81 Lund, Sweden.
Olesia WerbowyLaboratory of Extremophiles Biology, Department of Microbiology, Faculty of Biology, University of Gdansk, 80-822 Gdansk, Poland.
Anna-Karina KaczorowskaCollection of Plasmids and Microorganisms, Faculty of Biology, University of Gdansk, 80-308 Gdansk, Poland.
Tadeusz KaczorowskiLaboratory of Extremophiles Biology, Department of Microbiology, Faculty of Biology, University of Gdansk, 80-822 Gdansk, Poland.

Funding

H2020 European Research Council 685778National Science Center DEC-2019/03/X/NZ1/00394
6 · The paper itself

Abstract

Peptidoglycan hydrolytic enzymes are considered to be a promising alternative to conventional antibiotics in combating bacterial infections. To identify novel hydrolytic enzymes, we performed a database search with the sequences of two thermostable endolysins with high bactericidal activity, studied earlier in our laboratory. Both these enzymes originate from

Indexed as

Amino Acid SequenceBacterial ProteinsBacteriophagesCatalytic DomainClostridiumComputer SimulationConserved SequenceCrystallography, X-RayEndopeptidasesHydrophobic and Hydrophilic InteractionsInhibitory Concentration 50Microbial Sensitivity TestsModels, MolecularMutagenesis, Site-DirectedPeptide FragmentsProtein ConformationBacterial ProteinsendolysinEndopeptidasesPeptide FragmentsRecombinant ProteinsViral Proteinsantimicrobial peptideautolysinbacteriophageendolysinpeptidoglycanStaphylococcus aureusthermophiles

Identifiers

PMID32664473
PMCPMC7404271

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.