Evidence map›Paper›PMID 32664459›Full record

ArticleInternational journal of molecular sciences2020

Gram-Negative Bacterial Endotoxin LPS Induces NeuGc Loss through Ets1-Dependent Downregulation of Intestine-Specific

Choong-Hwan Kwak, Kwon-Ho Song, Cheorl-Ho Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Choong-Hwan KwakMolecular and Cellular Glycobiology Unit, Department of Biological Science, Sungkyunkwan University, Seoburo 2066, Jangan-Gu, Suwon, Gyunggi-Do 16419, Korea.
Kwon-Ho SongMolecular and Cellular Glycobiology Unit, Department of Biological Science, Sungkyunkwan University, Seoburo 2066, Jangan-Gu, Suwon, Gyunggi-Do 16419, Korea.
Cheorl-Ho KimMolecular and Cellular Glycobiology Unit, Department of Biological Science, Sungkyunkwan University, Seoburo 2066, Jangan-Gu, Suwon, Gyunggi-Do 16419, Korea.
Sungkyunkwan University · KR

Funding

National Research Foundation of Korea NRF-2018R1D1A1A09081927
6 · The paper itself

Abstract

N-glycolylneuraminic acid (NeuGc), a non-human sialic acid derivative synthesized by cytidine-5'-monophospho-N-acetylneuraminic acid hydroxylase (CMAH), plays a crucial role in mediating infections by certain pathogens. Although it has been postulated that NeuGc biosynthesis and CMAH expression are downregulated during microbial infection, the underlying mechanisms remain unclear. The present study showed that exposure to lipopolysaccharide (LPS), a Gram-negative bacterial endotoxin, leads to loss of NeuGc biosynthesis in pig small intestinal I2I-2I cells. This LPS-induced NeuGc loss was accompanied by decreased CMAH transcript levels, especially intestine-specific

Indexed as

AnimalsCell LineCytidine MonophosphateDown-RegulationEndotoxinsGram-Negative BacteriaIntestine, SmallLipopolysaccharidesMixed Function OxygenasesN-Acetylneuraminic AcidNeuraminic AcidsPromoter Regions, GeneticProto-Oncogene Protein c-ets-1Sialic AcidsSwinecytidine-5'-monophosphosialic acidCytidine MonophosphateEndotoxinsLipopolysaccharidesMixed Function OxygenasesN-Acetylneuraminic AcidNeuraminic AcidsN-glycolylneuraminic acidProto-Oncogene Protein c-ets-1Sialic Acidscytidine-5′-monophospho-N-acetylneuraminic acid hydroxylase (CMAH)Ets1lipopolysaccharide (LPS)N-glycolylneuraminic acid (NeuGc)

Identifiers

PMID32664459
PMCPMC7402312
OpenAlexW3042117730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.