Evidence map›Paper›PMID 32664387›Full record

ArticleBiomolecules2020

On the Risks of Phylogeny-Based Strain Prioritization for Drug Discovery:

Loïc Martinet, Aymeric Naômé, Dominique Baiwir, Edwin De Pauw, Gabriel Mazzucchelli, Sébastien Rigali

Abstract read
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Evaluation ofFrontiers in microbiology · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Antifungal Activity and Biosynthetic Potential of NewInternational journal of molecular sciences · 2021
    Article
  8. Microbial genomics · 2021
    Article
  9. Article
  10. Molecules (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Loïc MartinetInBioS-Centre for Protein Engineering, Institut de Chimie B6a, University of Liège, B-4000 Liège, Belgium.
Aymeric NaôméHedera-22, Boulevard du Rectorat 27b, B-4000 Liège, Belgium.
Dominique BaiwirGIGA Proteomics Facility, University of Liège, B-4000 Liège, Belgium.ORCID 0000-0002-1622-0118
Edwin De PauwMolSys Research Unit, Mass Spectrometry Laboratory, University of Liège, B-4000 Liège, Belgium.
Gabriel MazzucchelliMolSys Research Unit, Mass Spectrometry Laboratory, University of Liège, B-4000 Liège, Belgium.
Sébastien RigaliInBioS-Centre for Protein Engineering, Institut de Chimie B6a, University of Liège, B-4000 Liège, Belgium.ORCID 0000-0003-4022-7325

Funding

Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture FRIA1.E049.16
6 · The paper itself

Abstract

Strain prioritization for drug discovery aims at excluding redundant strains of a collection in order to limit the repetitive identification of the same molecules. In this work, we wanted to estimate what can be unexploited in terms of the amount, diversity, and novelty of compounds if the search is focused on only one single representative strain of a species, taking

Indexed as

Multigene FamilyAminobenzoatesBacterial ProteinsBiological ProductsBiosynthetic PathwaysData MiningFerrous CompoundsGenome, BacterialMetabolomicsNitroso CompoundsPhylogenySequence Analysis, DNAStreptomycesAminobenzoatesBacterial ProteinsBiological ProductsFerrous CompoundsferroverdinNitroso Compoundschemical diversitydrug discoverygenome miningmetabolomicsnatural productstrain prioritizationstreptomyces

Identifiers

PMID32664387
PMCPMC7408125

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.