Evidence map›Paper›PMID 32664217›Full record

ReviewNanomaterials (Basel, Switzerland)2020

Effects of Airborne Nanoparticles on the Nervous System: Amyloid Protein Aggregation, Neurodegeneration and Neurodegenerative Diseases.

Anna von Mikecz, Tamara Schikowski

Open access · goldAbstract readReview
In one paragraph

Review in Nanomaterials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Exposome, Molecular Pathways and One Health: The InvertebrateInternational journal of molecular sciences · 2022
    Review
  6. Article
  7. The In Vivo Toxicity Assessments of Water-Dispersed Fluorescent Silicon Nanoparticles inInternational journal of environmental research and public health · 2022
    Article
  8. Article
  9. Toxicology and Biocompatibility of Nanomaterials.Nanomaterials (Basel, Switzerland) · 2021
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Anna von MikeczIUF-Leibniz Research Institute for Environmental Medicine gGmbH, Heinrich-Heine-University, 40225 Duesseldorf, Germany.
Tamara SchikowskiIUF-Leibniz Research Institute for Environmental Medicine gGmbH, Heinrich-Heine-University, 40225 Duesseldorf, Germany.
Heinrich Heine University Düsseldorf · DELeibniz Institute of Environmental Medicine · DE

Funding

Deutsche Forschungsgemeinschaft MI 486/10-1
6 · The paper itself

Abstract

How the environment contributes to neurodegenerative diseases such as Alzheimer's is not well understood. In recent years, science has found augmenting evidence that nano-sized particles generated by transport (e.g., fuel combustion, tire wear and brake wear) may promote Alzheimer's disease (AD). Individuals residing close to busy roads are at higher risk of developing AD, and nanomaterials that are specifically generated by traffic-related processes have been detected in human brains. Since AD represents a neurodegenerative disease characterized by amyloid protein aggregation, this review summarizes our current knowledge on the amyloid-generating propensity of traffic-related nanomaterials. Certain nanoparticles induce the amyloid aggregation of otherwise soluble proteins in in vitro laboratory settings, cultured neuronal cells and vertebrate or invertebrate animal models. We discuss the challenges for future studies, namely, strategies to connect the wet laboratory with the epidemiological data in order to elucidate the molecular bio-interactions of airborne nanomaterials and their effects on human health.

Indexed as

air pollutionAlzheimer’s diseaseamyloidCaenorhabditis elegansCOVID-19dementianeurotoxicologyparticulate matterserotonintire wear

Identifiers

PMID32664217
PMCPMC7407104
OpenAlexW3040726604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.