Evidence map›Paper›PMID 32664211›Full record

ArticleMaterials (Basel, Switzerland)2020

Femtosecond Laser-Based Integration of Nano-Membranes into Organ-on-a-Chip Systems.

Liubov Bakhchova, Linas Jonušauskas, Dovilė Andrijec, Marharyta Kurachkina, Tomas Baravykas, Alexey Eremin, Ulrike Steinmann

Abstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Liubov BakhchovaInstitute for Automation Engineering, Otto von Guericke University Magdeburg, 39106 Magdeburg, Germany.
Linas JonušauskasFemtika Ltd., LT-10224 Vilnius, Lithuania.
Dovilė AndrijecFemtika Ltd., LT-10224 Vilnius, Lithuania.
Marharyta KurachkinaInstitute of Physics, Otto von Guericke University Magdeburg, 39106 Magdeburg, Germany.
Tomas BaravykasFemtika Ltd., LT-10224 Vilnius, Lithuania.
Alexey EreminInstitute of Physics, Otto von Guericke University Magdeburg, 39106 Magdeburg, Germany.
Ulrike SteinmannInstitute for Automation Engineering, Otto von Guericke University Magdeburg, 39106 Magdeburg, Germany.ORCID 0000-0002-4350-7093

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organ-on-a-chip devices are gaining popularity in medical research due to the possibility of performing extremely complex living-body-resembling research in vitro. For this reason, there is a substantial drive in developing technologies capable of producing such structures in a simple and, at the same time, flexible manner. One of the primary challenges in producing organ-on-chip devices from a manufacturing standpoint is the prevalence of layer-by-layer bonding techniques, which result in limitations relating to the applicable materials and geometries and limited repeatability. In this work, we present an improved approach, using three dimensional (3D) laser lithography for the direct integration of a functional part-the membrane-into a closed-channel system. We show that it allows the freely choice of the geometry of the membrane and its integration into a complete organ-on-a-chip system. Considerations relating to sample preparation, the writing process, and the final preparation for operation are given. Overall, we consider that the broader application of 3D laser lithography in organ-on-a-chip fabrication is the next logical step in this field's evolution.

Indexed as

adaptable membranesfemtosecond lasermicrofluidic channelorgan-on-a-chippoly-dimethyl siloxane (PDMS)

Identifiers

PMID32664211
PMCPMC7412128

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.