Evidence map›Paper›PMID 32663968›Full record

ArticleJournal of affective disorders2020

The neural basis of hot and cold cognition in depressed patients, unaffected relatives, and low-risk healthy controls: An fMRI investigation.

Nord Cl, Halahakoon Dc, Lally N, Limbachya T, Pilling S, Roiser Jp

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  9. Depressive symptoms in youth with ADHD: the role of impairments in cognitive emotion regulation.European archives of psychiatry and clinical neuroscience · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Nord ClInstitute of Cognitive Neuroscience, University College London, London, UK; MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK. Electronic address: Camilla.Nord@mrc-cbu.cam.ac.uk.
Halahakoon DcInstitute of Cognitive Neuroscience, University College London, London, UK; Department of Psychiatry, University of Oxford, Oxford, UK.
Lally NInstitute of Cognitive Neuroscience, University College London, London, UK; Warwick Medical School, University of Warwick, Coventry, UK; Experimental Therapeutics & Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA.
Limbachya TCamden and Islington NHS Foundation Trust, London, UK.
Pilling SDepartment of Clinical, Educational, and Health Psychology, University College London, London, UK.
Roiser JpInstitute of Cognitive Neuroscience, University College London, London, UK.
University College London · GBCamden and Islington NHS Foundation Trust · GBMRC Cognition and Brain Sciences Unit · GBNational Institutes of Health · USUniversity of Oxford · GB

Funding

Department of HealthMedical Research Council MC_U105579215Medical Research Council SUAG/043/G101400
6 · The paper itself

Abstract

backgroundModern cognitive neuropsychological models of depression posit that negatively biased emotional ("hot") processing confers risk for depression, while preserved executive function ("cold") cognition promotes resilience.

methodsWe compared neural responses during hot and cold cognitive tasks in 99 individuals: those at familial risk for depression (N = 30 unaffected first-degree relatives of depressed individuals) and those currently experiencing a major depressive episode (N = 39 unmedicated depressed patients) with low-risk healthy controls (N = 30). Primary analyses assessed neural activation on two functional magnetic resonance imaging tasks previously associated with depression: dorsolateral prefrontal cortex (DLPFC) responsivity during the n-back working memory task; and amygdala and subgenual anterior cingulate cortex (sgACC) responsivity during incidental emotional face processing.

resultsDepressed patients exhibited significantly attenuated working memory-related DLPFC activation, compared to low-risk controls and unaffected relatives; unaffected relatives did not differ from low-risk controls. We did not observe a complementary pattern during emotion processing. However, we found preliminary support that greater DLPFC activation was associated with lower amygdala response during emotion processing. LIMITATIONS: These findings require confirmation in a longitudinal study to observe each individual's risk of developing depression; without this, we cannot identify the true risk level of the first-degree relative or low-risk control group.

conclusionsThese findings have implications for understanding the neural mechanisms of risk and resilience in depression: they are consistent with the suggestion that preserved executive function might confer resilience to developing depression in first-degree relatives of depressed patients.

Indexed as

Magnetic Resonance ImagingMajor Depressive DisorderBrain MappingCognitionEmotionsHumansLongitudinal StudiesPrefrontal CortexAmygdalaDepressionDLPFCEmotion processingWorking memory

Identifiers

PMID32663968
PMCPMC7369634
OpenAlexW3026431920

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.