ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2020
Sex and strain differences in dynamic and static properties of the mesolimbic dopamine system.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Dopaminergic modulation of reward discounting in healthy rats: a systematic review and meta-analysis.Psychopharmacology · 2021Pooled it
- dCA1 cells encode and update contextual place preference.Frontiers in systems neuroscience · 2026Article
- Ventral Striatal Cholinergic Interneurons Regulate Decision-Making or Motor Impulsivity Differentially across Learning and Biological Sex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Cross-species dissection of the modular role of the ventral tegmental area in depressive disorders.Neuroscience · 2025Review
- Devaluing memories of reward: a case for dopamine.Communications biology · 2025Article
- Interactions of sex and stress in modulation of ventral tegmental area dopaminergic activity.Current opinion in behavioral sciences · 2025Article
- Social isolation postweaning alters reward-related dopamine dynamics in a region-specific manner in adolescent male rats.Neurobiology of stress · 2024Article
- Analysis of risk factors for hospital-acquired pneumonia in schizophrenia.Frontiers in psychiatry · 2024Review
- Sex-based influential factors for dental caries in patients with schizophrenia.BMC psychiatry · 2023Article
- Transient strain differences in an operant delayed non-match to position task.Behavioural processes · 2023Article
- Elevated prefrontal dopamine interferes with the stress-buffering properties of behavioral control in female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Sex Differences in Psychosis: Focus on Animal Models.Current topics in behavioral neurosciences · 2023Review
- Sex differences in chronic pain-induced mental disorders: Mechanisms of cerebral circuitry.Frontiers in molecular neuroscience · 2023Review
- Cocaine intake correlates with risk-taking behavior and affects estrous cycling in female Sprague-Dawley rats.Frontiers in behavioral neuroscience · 2023Article
- Sex differences in factors influencing hospital-acquired pneumonia in schizophrenia patients receiving modified electroconvulsive therapy.Frontiers in psychiatry · 2023Article
- The reward for placebos: mechanisms underpinning placebo-induced effects on motor performance.European journal of applied physiology · 2022Review
- Effects of Early Life Exposure to Sex Hormones on Neurochemical and Behavioral Responses to Psychostimulants in Adulthood: Implications in Drug Addiction.International journal of molecular sciences · 2022Article
- An atlas of transcriptionally defined cell populations in the rat ventral tegmental area.Cell reports · 2022Article
- Adolescent Dopamine Neurons Represent Reward Differently during Action and State Guided Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Sex is a biological variable that contributes to the incidence, clinical course, and treatment outcome of brain disorders. Chief among these are disorders associated with the dopamine system. These include Parkinson's disease, ADHD, schizophrenia, and mood disorders, which show stark differences in prevalence and outcome between men and women. In order to reveal the influence of biological sex as a risk factor in these disorders, there is a critical need to collect fundamental information about basic properties of the dopamine system in males and females. In Long Evans rats, we measured dynamic and static properties related to the mesolimbic dopamine system. Static measures included assessing ventral tegmental area (VTA) dopamine cell number and volume and expression of tyrosine hydroxylase and dopamine transporter. Dynamic measures in behaving animals included assessing (1) VTA neuronal encoding during learning of a cue-action-reward instrumental task and (2) dopamine release in the nucleus accumbens in response to electrical stimulation of the VTA, vesicular depletion of dopamine, and amphetamine. We found little or no sex difference in these measures, suggesting sexual congruency in fundamental static and dynamic properties of dopamine neurons. Thus, dopamine related sex-differences are likely mediated by secondary mechanisms that flexibly influence the function of the dopamine cells and circuits. Finally, we noted that most behavioral sex differences had been reported in Sprague-Dawley rats and repeated some of the above measures in that strain. We found some sex differences in those animals highlighting the importance of considering strain differences in experimental design and result interpretation.
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