Evidence map›Paper›PMID 32663717›Full record

ArticleNeurobiology of aging2020

Calbindin-D

Sydney Lamerand, Ryan Shahidehpour, Ivan Ayala, Tamar Gefen, M-Marsel Mesulam, Eileen Bigio, Changiz Geula

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Shades of gray in human white matter.The Journal of comparative neurology · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sydney LamerandMesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Ryan ShahidehpourMesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Ivan AyalaMesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Tamar GefenMesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
M-Marsel MesulamMesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Eileen BigioMesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Changiz GeulaMesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address: c-geula@northwestern.edu.
Northwestern University · US

Funding

NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8M
Neuropathology CoreP30AG013854 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BIGIO, EILEEN H. · 1996 to 2020
$28.9M
Predoctorial Training in Basic NeuroscienceT32NS007433 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MERINEY, STEPHEN D · 1998 to 2022
$8.0M
CALBINDIN AND CHOLINERGIC NEURONS IN AGING AND ADR01AG014706 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GEULA, CHANGIZ · 1999 to 2002
$830k
CaMKI, Apoptosis and Cholinergic Neurons in Aging and ADR03AG027141 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GEULA, CHANGIZ · 2006 to 2007
$139k
NIA NIH HHS P30 AG013854NIA NIH HHS R01 AG014706NIA NIH HHS R03 AG027141NIA NIH HHS U01 AG016976NINDS NIH HHS T32 NS007433
6 · The paper itself

Abstract

Certain neuronal populations, including basal forebrain cholinergic neurons (BFCN) and noradrenergic neurons of the locus coeruleus (LC), are selectively vulnerable to pathology and loss early in the course of aging and Alzheimer's disease (AD). Human BFCN show substantial loss of the calcium-binding protein (CBP), calbindin-D

Indexed as

Adrenergic NeuronsAdultAgedAgingAlzheimer DiseaseCalbindin 1Calbindin 2Cholinergic NeuronsFemaleHumansLocus CoeruleusMaleMiddle AgedNeurofibrillary TanglesParvalbuminsYoung AdultCalbindin 1Calbindin 2ParvalbuminsAlzheimer's diseaseCalbindin-D(28k)Calcium-binding proteinsLocus coeruleusNoradrenergic

Identifiers

PMID32663717
PMCPMC7483964
OpenAlexW3035364372

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.