Evidence map›Paper›PMID 32663656›Full record

ArticleProstaglandins, leukotrienes, and essential fatty acids2020

Stearic acid methyl ester affords neuroprotection and improves functional outcomes after cardiac arrest.

Po-Yi Chen, Celeste Yin-Chieh Wu, Garrett A Clemons, Cristiane T Citadin, Alexandre Couto E Silva, Harlee E Possoit, Rinata Azizbayeva, Nathan E Forren, Chin-Hung Liu, K N Shashanka Rao and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Prostaglandins, leukotrienes, and essential fatty acids, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Hepatoprotective activity ofFrontiers in cellular and infection microbiology · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Po-Yi ChenCenter for Brain Health, Louisiana State University Health Sciences Center, Shreveport, LA; Department of Neurology, Louisiana State University, Health Sciences Center, Shreveport, LA; Cardiovascular Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; Department of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; PhD. Programs in Pharmacology and Toxicology, College of Medicine, Tzu Chi University, Hualien, Taiwan.
Celeste Yin-Chieh WuCenter for Brain Health, Louisiana State University Health Sciences Center, Shreveport, LA; Department of Neurology, Louisiana State University, Health Sciences Center, Shreveport, LA.
Garrett A ClemonsCenter for Brain Health, Louisiana State University Health Sciences Center, Shreveport, LA; Department of Cellular Biology and Anatomy, Louisiana State University, Health Sciences Center, Shreveport, LA.
Cristiane T CitadinCenter for Brain Health, Louisiana State University Health Sciences Center, Shreveport, LA; Department of Cellular Biology and Anatomy, Louisiana State University, Health Sciences Center, Shreveport, LA.
Alexandre Couto E SilvaCenter for Brain Health, Louisiana State University Health Sciences Center, Shreveport, LA; Department of Cellular Biology and Anatomy, Louisiana State University, Health Sciences Center, Shreveport, LA.
Harlee E PossoitCenter for Brain Health, Louisiana State University Health Sciences Center, Shreveport, LA; Department of Neurology, Louisiana State University, Health Sciences Center, Shreveport, LA.
Rinata AzizbayevaDepartment of Biomedical Science, West Virginia University School of Osteopathic Medicine, Lewisburg, WV.
Nathan E ForrenDepartment of Biomedical Science, West Virginia University School of Osteopathic Medicine, Lewisburg, WV.
Chin-Hung LiuCardiovascular Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; PhD. Programs in Pharmacology and Toxicology, College of Medicine, Tzu Chi University, Hualien, Taiwan.
K N Shashanka RaoDepartment of Cellular Biology and Anatomy, Louisiana State University, Health Sciences Center, Shreveport, LA.
David M KrzywanskiDepartment of Cellular Biology and Anatomy, Louisiana State University, Health Sciences Center, Shreveport, LA.
Reggie Hui-Chao LeeCenter for Brain Health, Louisiana State University Health Sciences Center, Shreveport, LA; Department of Neurology, Louisiana State University, Health Sciences Center, Shreveport, LA.
Jake T NeumannDepartment of Biomedical Science, West Virginia University School of Osteopathic Medicine, Lewisburg, WV.
Hung Wen LinCenter for Brain Health, Louisiana State University Health Sciences Center, Shreveport, LA; Department of Cellular Biology and Anatomy, Louisiana State University, Health Sciences Center, Shreveport, LA; Department of Neurology, Louisiana State University, Health Sciences Center, Shreveport, LA. Electronic address: hlin2@lsuhsc.edu.
Louisiana State University Health Sciences Center Shreveport · USWest Virginia School of Osteopathic Medicine · USHualien Tzu Chi Medical Center · TWTzu Chi Foundation · TWWest Virginia University · US

Funding

American Heart Association-American Stroke Association 17GRNT33660336American Heart Association-American Stroke Association 19POST34380784American Heart Association-American Stroke Association 19TPA34850047
6 · The paper itself

Abstract

Cardiac arrest causes neuronal damage and functional impairments that can result in learning/memory dysfunction after ischemia. We previously identified a saturated fatty acid (stearic acid methyl ester, SAME) that was released from the superior cervical ganglion (sympathetic ganglion). The function of stearic acid methyl ester is currently unknown. Here, we show that SAME can inhibit the detrimental effects of global cerebral ischemia (i.e. cardiac arrest). Treatment with SAME in the presence of asphyxial cardiac arrest (ACA) revived learning and working memory deficits. Similarly, SAME-treated hippocampal slices after oxygen-glucose deprivation inhibited neuronal cell death. Moreover, SAME afforded neuroprotection against ACA in the CA1 region of the hippocampus, reduced ionized calcium-binding adapter molecule 1 expression and inflammatory cytokines/chemokines, with restoration in mitochondria respiration. Altogether, we describe a unique and uncharted role of saturated fatty acids in the brain that may have important implications against cerebral ischemia.

Indexed as

AnimalsAsphyxiaCA1 Region, HippocampalDisease Models, AnimalHeart ArrestMaleNeuroprotectionRatsRats, Sprague-DawleyStearic AcidsStearic AcidsAsphyxial cardiac arrest (ACA)Cerebral ischemiaHippocampusLong chain saturated fatty acidNeuroinflammationNeuroprotectionStearic acid methyl ester (SAME)

Identifiers

PMID32663656
PMCPMC11192438
OpenAlexW3026994484

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.