Observational studyThe American journal of medicine2021
The Diagnoses and Outcomes of Emergency Patients With an Elevated D-Dimer Over the Next 90 Days.
Observational study in The American journal of medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- D-dimer levels and outcomes in heart failure with mildly reduced ejection fraction.International journal of cardiology. Heart & vasculature · 2026Article
- Short- and long-term risk stratification in acutely ill medical patients by implementing D-dimer in the emergency setting - A prospective cohort study.American heart journal plus : cardiology research and practice · 2026Article
- Elevated D-dimer is independently associated with in-hospital mortality in patients withFrontiers in cellular and infection microbiology · 2026Article
- Nonspecific stress biomarkers for mortality prediction in older emergency department patients presenting with falls: a prospective multicenter observational study.Internal and emergency medicine · 2025Observational
- Anemia Risk Prediction Model for Osteosarcoma Patients Post-Chemotherapy Using Artificial Intelligence.Cancer medicine · 2024Article
- Scurvy in a young man: a rare case report.Frontiers in nutrition · 2023Article
- The Reply.The American journal of medicine · 2021Article
- Routine measurement of d-dimers on suspected SARS-CoV2-infected patients does not lead to significant increase in radiological investigations.Internal and emergency medicine · 2021Article
- Unexpected Pulmonary Embolism Late After Recovery from Mild COVID-19?European journal of case reports in internal medicine · 2021Article
- Analysis of perioperative risk factors for deep vein thrombosis in patients with femoral and pelvic fractures.Journal of orthopaedic surgery and research · 2020Article
- Systematic review and meta-analysis of studies comparing baseline D-dimer level in stroke patients with or without cancer: Strength of current evidence.Journal of neurosciences in rural practiceReview
Corrections and comments
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- Commented on byThe Reply.2021
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is not known what diagnoses are associated with an elevated D-dimer in unselected patients attending emergency departments (ED), nor have their associated outcomes been determined.
methodsThis was a prospective observational study of 1612 unselected patients attending a Danish ED, with 100% follow-up for 90 days after presentation.
resultsThe 765 (47%) ED patients with an elevated D-dimer level (ie, ≥ 0.5 mg/L) were more likely to be admitted to hospital (P <.0001), re-present to health services (P = .02), and die within 90 days (8.1% of patients, P <.0001). Only 10 patients with a normal D-dimer level (1.2%) died within 90 days. Five had chronic obstructive pulmonary disease and infection, and 5 had cancer (4 of whom also had infection). Venous thromboembolism, infection, neoplasia, anemia, heart failure, and unspecified soft tissue disorders were significantly associated with an elevated D-dimer level. Of the 72 patients with venous thromboembolism, 20 also had infection, 8 had cancer, and 4 had anemia. None of the patients with heart failure, stroke, or acute myocardial infarction with a normal D-dimer level died within 90 days.
conclusionsIn this study, nearly half of all patients attending the ED had an elevated D-dimer level, and these patients were more likely to be admitted to hospital and to re-present to health services or die within 90 days. In this unselected ED patient population, elevated D-dimer levels were found to not only be significantly associated with venous thromboembolism, but to also be associated with infection, cancer, heart failure, and anemia.
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