ArticleJournal of behavioral addictions2020
Inhibitory neuromodulation of the putamen to the prefrontal cortex in Internet gaming disorder: How addiction impairs executive control.
Article in Journal of behavioral addictions, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Neural mechanisms of behavioral addiction: An ALE meta-analysis and MACM analysis.Journal of behavioral addictions · 2025Pooled it
- Functional Neural Alterations in Pathological Internet Use: A Meta-Analysis of Neuroimaging Studies.Frontiers in neurology · 2022Pooled it
- Structural and Functional Brain Abnormalities in Internet Gaming Disorder and Attention-Deficit/Hyperactivity Disorder: A Comparative Meta-Analysis.Frontiers in psychiatry · 2021Pooled it
- Exploring Gambling-like Behaviors in Children's Cigarette Card Games and Parental Pro-game Perceptions in China: A Qualitative Study.Journal of gambling studies · 2026Article
- Effects of Progressive Aerobic Training on Executive-Reward Network Connectivity and Symptoms of Internet Gaming Disorder: Randomized Controlled Trial.JMIR serious games · 2025Article
- Individual-specific subspace of altered functional connectivity predicts clinical symptoms in Internet gaming disorder.Journal of behavioral addictions · 2025Article
- Anxiety and inhibitory control play a chain mediating role between compassion fatigue and Internet addiction disorder among nursing staff.Scientific reports · 2025Article
- Gaming disorder: Neural mechanisms and ongoing debates.Journal of behavioral addictions · 2025Review
- The chain mediating effect of anxiety and inhibitory control between bullying victimization and internet addiction in adolescents.Scientific reports · 2024Article
- Biomarkers of Internet Gaming Disorder-A Narrative Review.Journal of clinical medicine · 2024Review
- Video game addiction is associated with early stage of inhibitory control problems: An event-related potential study using cued Go/NoGo task.Addiction biology · 2024Article
- Ten years of research on the treatments of internet gaming disorder: A scoping review and directions for future research.Journal of behavioral addictions · 2024Article
- Static and dynamic changes of intrinsic brain local connectivity in internet gaming disorder.BMC psychiatry · 2023Article
- Lower synaptic density associated with gaming disorder: anGeneral psychiatry · 2023Article
- Overview on brain function enhancement of Internet addicts through exercise intervention: Based on reward-execution-decision cycle.Frontiers in psychiatry · 2023Review
- Sex differences in neural substrates of risk taking: Implications for sex-specific vulnerabilities to internet gaming disorder.Journal of behavioral addictions · 2022Article
- Dorsal and ventral striatal functional connectivity shifts play a potential role in internet gaming disorder.Communications biology · 2021Article
- Gender-related differences in frontal-parietal modular segregation and altered effective connectivity in internet gaming disorder.Journal of behavioral addictions · 2021Article
- Resting-State Functional Connectivity between Putamen and Salience Network and Childhood Body Mass Index.Neurology international · 2021Article
- Monetary Reward Discounting, Inhibitory Control, and Trait Impulsivity in Young Adults With Internet Gaming Disorder and Nicotine Dependence.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsIndividuals with addictive disorders are usually characterized by impaired executive control, persistent craving and excessive reward-seeking. However, it is unclear whether there is a deviation in the connection pattern among the neural systems implicated in these problem behaviors.
methodsOne hundred thirty-six online gaming players were recruited in the current study (68 Internet gaming disorder (IGD) subjects and 68 recreational game users (RGUs) who served as controls matched on age, sex, years of education, and years of gaming). Dynamic interactions among the reward system (striatum), control system (prefrontal cortex), and the interoceptive awareness system (insula) were calculated and compared when subjects were facing gaming cues.
resultsThe results revealed that RGUs showed a significant positive correlation in the putamen-middle frontal gyrus (MFG)-insula neural pathway when facing gaming cues, which was missing in the IGD subjects. Additionally, dynamic causal modeling (DCM) analysis revealed that the MFG region was more inhibited by the putamen in the IGD subjects relative to the RGUs.
conclusionsThese findings suggest that the inhibitory neuromodulation of the putamen to the prefrontal cortex in IGD individuals undermines the balance among the tripartite systems. Our findings provide novel neurobiological evidence for understanding the internal connection bias of the addicted individual's neural system and how the addictive disorder impairs executive control; consequently, the pathway from the striatum to the prefrontal cortex may serve as a potential biomarker to predict the risk of developing an addiction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.