ReviewThe European journal of neuroscience2021
The ins and outs of inhibitory synaptic plasticity: Neuron types, molecular mechanisms and functional roles.
Review in The European journal of neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Synaptic plasticity of prefrontal long-range inhibition regulates cognitive flexibility.Neuron · 2026Article
- Article
- Tuning excitatory input to fast-spiking parvalbumin-positive interneurons: a lever for plasticity and hyperexcitability across the lifespan.Frontiers in synaptic neuroscience · 2026Article
- Satellite microglia gate neuronal excitability by shielding inhibitory synapses in adult brain.bioRxiv : the preprint server for biology · 2025Article
- Inhibition of SERT and NMDAR synergistically confers rapid antidepressant effects of ketamine.National science review · 2025Article
- Article
- Dendritic Inhibition Effects in Memory Retrieval of a Neuromorphic Microcircuit Model of the Rat Hippocampus.Brain sciences · 2025Article
- Unveiling the role of local metabolic constraints on the structure and activity of spiking neural networks.PLoS computational biology · 2025Article
- An anti-Hebbian model for binocular visual plasticity and its attentional modulation.Communications biology · 2025Article
- Neuronal traveling waves form preferred pathways using synaptic plasticity.Journal of computational neuroscience · 2025Article
- Neural Mass Modeling in the Cortical Motor Area and the Mechanism of Alpha Rhythm Changes.Sensors (Basel, Switzerland) · 2024Article
- Postsynaptic dopamine DJournal of neurophysiology · 2024Article
- Learning-induced remodelling of inhibitory synapses in the motor cortex.Open biology · 2024Article
- Ultrastructural characterization of hippocampal inhibitory synapses under resting and stimulated conditions.Molecular brain · 2024Article
- Cell-type specific inhibitory plasticity in subicular pyramidal cells.Frontiers in cellular neuroscience · 2024Article
- Anatomical and molecular development of the human primary visual cortex.Frontiers in cellular neuroscience · 2024Review
- Interneuronal modulations as a functional switch for cortical computations: mechanisms and implication for disease.Frontiers in cellular neuroscience · 2024Article
- Hippocampal GABAergic interneurons and memory.Neuron · 2023Review
- S-Palmitoylation of Synaptic Proteins in Neuronal Plasticity in Normal and Pathological Brains.Cells · 2023Review
- Model of ligand-triggered information transmission in G-protein coupled receptor complexes.Frontiers in endocrinology · 2023Article
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3 authors.
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Abstract
GABAergic interneurons are highly diverse, and their synaptic outputs express various forms of plasticity. Compelling evidence indicates that activity-dependent changes of inhibitory synaptic transmission play a significant role in regulating neural circuits critically involved in learning and memory and circuit refinement. Here, we provide an updated overview of inhibitory synaptic plasticity with a focus on the hippocampus and neocortex. To illustrate the diversity of inhibitory interneurons, we discuss the case of two highly divergent interneuron types, parvalbumin-expressing basket cells and neurogliaform cells, which support unique roles on circuit dynamics. We also present recent progress on the molecular mechanisms underlying long-term, activity-dependent plasticity of fast inhibitory transmission. Lastly, we discuss the role of inhibitory synaptic plasticity in neuronal circuits' function. The emerging picture is that inhibitory synaptic transmission in the CNS is extremely diverse, undergoes various mechanistically distinct forms of plasticity and contributes to a much more refined computational role than initially thought. Both the remarkable diversity of inhibitory interneurons and the various forms of plasticity expressed by GABAergic synapses provide an amazingly rich inhibitory repertoire that is central to a variety of complex neural circuit functions, including memory.
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