Evidence map›Paper›PMID 32663348›Full record

ReviewAngewandte Chemie (International ed. in English)2020

Current Status of COVID-19 (Pre)Clinical Vaccine Development.

Tingting Ye, Zifu Zhong, Adolfo García-Sastre, Michael Schotsaert, Bruno G De Geest

Abstract readReview
In one paragraph

Review in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Mucus-Inspired Dynamic Hydrogels: Synthesis and Future Perspectives.Journal of the American Chemical Society · 2022
    Review
  7. Current clinical status of new COVID-19 vaccines and immunotherapy.Environmental science and pollution research international · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Peptides for Vaccine Development.ACS applied bio materials · 2022
    Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. β-Glucans Could Be Adjuvants for SARS-CoV-2 Virus Vaccines (COVID-19).International journal of environmental research and public health · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tingting YeDepartment of Pharmaceutics, Ghent University, Belgium.
Zifu ZhongDepartment of Pharmaceutics, Ghent University, Belgium.
Adolfo García-SastreDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Michael SchotsaertDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Bruno G De GeestDepartment of Pharmaceutics, Ghent University, Belgium.ORCID 0000-0001-9826-6170

Funding

COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTER: UNIVERSAL INFLUENZA VACCINE RESEARCH75N93019C00051 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KRAMMER, FLORIAN · 2019 to 2025
$105.4M
SARS-CoV adaptations through a Systems Biology Lens (SYBIL)U19AI135972 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Adolfo Garcia-Sastre · 2018 to 2026
$27.2M
Technology Development Project - Increasing the complexity of ex vivo human airway models for studying immune response to viral infectionU19AI142733 · NIAID · JACKSON LABORATORY · PI Damien Chaussabel · 2019 to 2026
$23.1M
Mechanisms Controlling Expansion and Lineage Specification of Airway Progenitors in Development and DiseaseR35HL135834 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CARDOSO, WELLINGTON V. · 2017 to 2023
$6.7M
A Miniature Pig Model for the Study of Host-Immune Responses Against Influenza A VirusR21AI151229 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RICHT, JUERGEN A, SCHOTSAERT, MICHAEL · 2020 to 2021
$457k
NHLBI NIH HHS R35 HL135834NIAID NIH HHS 75N93019C00051NIAID NIH HHS HHSN272201400008CNIAID NIH HHS HHSN272201800048CNIAID NIH HHS R21 AI151229NIAID NIH HHS U19 AI135972NIAID NIH HHS U19 AI142733
6 · The paper itself

Abstract

The current COVID-19 pandemic has a tremendous impact on daily life world-wide. Despite the ability to dampen the spread of SARS-CoV-2, the causative agent of the diseases, through restrictive interventions, it is believed that only effective vaccines will provide sufficient control over the disease and revert societal live back to normal. At present, a double-digit number of efforts are devoted to the development of a vaccine against COVID-19. Here, we provide an overview of these (pre)clinical efforts and provide background information on the technologies behind these vaccines. In addition, we discuss potential hurdles that need to be addressed prior to mass scale clinical translation of successful vaccine candidates.

Indexed as

COVID-19COVID-19 VaccinesGenetic VectorsHumansSARS-CoV-2Vaccines, DNAVaccines, InactivatedVaccines, Virus-Like ParticleCOVID-19 VaccinesVaccines, DNAVaccines, InactivatedVaccines, Virus-Like ParticleCOVID-19pandemicSARS-CoV-2vaccine

Identifiers

PMID32663348
PMCPMC7405471

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.