Evidence map›Paper›PMID 32663221›Full record

ArticlePLoS biology2020

Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0.

Nathalie Percie du Sert, Amrita Ahluwalia, Sabina Alam, Marc T Avey, Monya Baker, William J Browne, Alejandra Clark, Innes C Cuthill, Ulrich Dirnagl, Michael Emerson and 18 more

Abstract read
In one paragraph

Article in PLoS biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,568 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,568citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,568 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Mapping molluscan endocrinology: a systematic and critical appraisal.Biological reviews of the Cambridge Philosophical Society · 2026
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Oncoimmunology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

1,508 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Nathalie Percie du SertNC3Rs, London, United Kingdom.ORCID 0000-0002-9478-0540
Amrita AhluwaliaThe William Harvey Research Institute, London, United Kingdom.ORCID 0000-0001-7626-6399
Sabina AlamTaylor & Francis Group, London, United Kingdom.ORCID 0000-0002-8615-9658
Marc T AveyHealth Science Practice, ICF, Durham, North Carolina, United States of America.ORCID 0000-0002-8696-3232
Monya BakerNature, San Francisco, California, United States of America.
William J BrowneSchool of Education, University of Bristol, Bristol, United Kingdom.ORCID 0000-0002-6659-6885
Alejandra ClarkPLOS ONE, Cambridge, United Kingdom.ORCID 0000-0002-1292-0408
Innes C CuthillSchool of Biological Sciences, University of Bristol, Bristol, United Kingdom.ORCID 0000-0002-5007-8856
Ulrich DirnaglQUEST Center for Transforming Biomedical Research, Berlin Institute of Health & Department of Experimental Neurology, Charite Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0003-0755-6119
Michael EmersonNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Paul GarnerCentre for Evidence Synthesis in Global Health, Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.ORCID 0000-0002-0607-6941
Stephen T HolgateClinical and Experimental Sciences, University of Southampton, Southampton, United Kingdom.
David W HowellsTasmanian School of Medicine, University of Tasmania, Hobart, Australia.ORCID 0000-0002-2512-7724
Viki HurstNC3Rs, London, United Kingdom.
Natasha A KarpData Sciences & Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.ORCID 0000-0002-8404-2907
Stanley E LazicPrioris.ai Inc, Ottawa, Canada.
Katie LidsterNC3Rs, London, United Kingdom.
Catriona J MacCallumHindawi Ltd, London, United Kingdom.ORCID 0000-0001-9623-2225
Malcolm MacleodCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0001-9187-9839
Esther J PearlNC3Rs, London, United Kingdom.ORCID 0000-0001-6510-0959
Ole H PetersenAcademia Europaea Knowledge Hub, Cardiff University, Cardiff, United Kingdom.
Frances RawleMedical Research Council, London, United Kingdom.ORCID 0000-0002-8877-6262
Penny ReynoldsStatistics in Anesthesiology Research (STAR) Core, Department of Anesthesiology, College of Medicine, University of Florida, Gainesville, Florida, United States of America.ORCID 0000-0001-7480-6275
Kieron RooneyDiscipline of Exercise and Sport Science, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.ORCID 0000-0001-6563-7617
Emily S SenaCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0002-3282-8502
Shai D SilberbergNational Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United States of America.
Thomas StecklerJanssen Pharmaceutica NV, Beerse, Belgium.ORCID 0000-0002-9927-5121
Hanno WürbelVeterinary Public Health Institute, Vetsuisse Faculty, University of Bern, Bern, Switzerland.ORCID 0000-0002-2934-3010

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Improving the reproducibility of biomedical research is a major challenge. Transparent and accurate reporting is vital to this process; it allows readers to assess the reliability of the findings and repeat or build upon the work of other researchers. The ARRIVE guidelines (Animal Research: Reporting In Vivo Experiments) were developed in 2010 to help authors and journals identify the minimum information necessary to report in publications describing in vivo experiments. Despite widespread endorsement by the scientific community, the impact of ARRIVE on the transparency of reporting in animal research publications has been limited. We have revised the ARRIVE guidelines to update them and facilitate their use in practice. The revised guidelines are published alongside this paper. This explanation and elaboration document was developed as part of the revision. It provides further information about each of the 21 items in ARRIVE 2.0, including the rationale and supporting evidence for their inclusion in the guidelines, elaboration of details to report, and examples of good reporting from the published literature. This document also covers advice and best practice in the design and conduct of animal studies to support researchers in improving standards from the start of the experimental design process through to publication.

Indexed as

Animal ExperimentationGuidelines as TopicResearch ReportAnimal HusbandryAnimalsConfidence IntervalsHousing, AnimalOutcome Assessment, Health CarePublicationsRandom AllocationReproducibility of ResultsSample Size

Identifiers

PMID32663221
PMCPMC7360025

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.