Evidence map›Paper›PMID 32663192›Full record

ArticleThe Journal of clinical investigation2020

SIV infection duration largely determines broadening of neutralizing antibody response in macaques.

Fan Wu, Ilnour Ourmanov, Andrea Kirmaier, Sivan Leviyang, Celia LaBranche, Jinghe Huang, Sonya Whitted, Kenta Matsuda, David Montefiori, Vanessa M Hirsch

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Fan WuShanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Ilnour OurmanovLaboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
Andrea KirmaierBiology Department, Boston College, Chestnut Hill, Massachusetts, USA.
Sivan LeviyangDepartment of Mathematics and Statistics, Georgetown University, Washington, DC, USA.
Celia LaBrancheDepartment of Surgery, Duke University School of Medicine, Durham, North Carolina, USA.
Jinghe HuangShanghai Medical College, Fudan University, Shanghai, China.
Sonya WhittedLaboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
Kenta MatsudaLaboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
David MontefioriDepartment of Surgery, Duke University School of Medicine, Durham, North Carolina, USA.
Vanessa M HirschLaboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.
National Institute of Allergy and Infectious Diseases · USDuke University · USBoston College · USGeorgetown University · USShanghai Medical College of Fudan University · CNShanghai Public Health Clinical Center · CN

Funding

Pathogenesis Studies Of Simian Immunodeficiency Virus Infection Of MonkeysZIAAI000370 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HIRSCH, VANESSA M. · 2009 to 2022
$16.2M
NIAID NIH HHS HHSN272201100016C
6 · The paper itself

Abstract

The development of broadly neutralizing antibodies (BNAbs) in HIV infection is a result of long-term coevolutionary interaction between viruses and antibodies. Understanding how this interaction promotes the increase of neutralization breadth during infection will improve the way in which AIDS vaccine strategies are designed. In this paper, we used SIV-infected rhesus macaques as a model to study the development of neutralization breadth by infecting rhesus macaques with longitudinal NAb escape variants and evaluating the kinetics of NAb response and viral evolution. We found that the infected macaques developed a stepwise NAb response against escape variants and increased neutralization breadth during the course of infection. Furthermore, the increase of neutralization breadth correlated with the duration of infection but was independent of properties of the inoculum, viral loads, or viral diversity during infection. These results imply that the duration of infection was the main factor driving the development of BNAbs. These data suggest the importance of novel immunization strategies to induce effective NAb response against HIV infection by mimicking long-term infection.

Indexed as

AIDS VaccinesAnimalsAntibodies, NeutralizingAntibodies, ViralAntigens, ViralBroadly Neutralizing AntibodiesGenetic VariationHIV InfectionsHumansImmune EvasionMacaca mulattaModels, ImmunologicalSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusTime FactorsVirus ReplicationAIDS VaccinesAntibodies, NeutralizingAntibodies, ViralAntigens, ViralBroadly Neutralizing AntibodiesAIDS/HIVGenetic variationImmunoglobulinsVirology

Identifiers

PMID32663192
PMCPMC7524488
OpenAlexW3043413147

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.