Evidence map›Paper›PMID 32663059›Full record

ArticleGut microbes2020

The gut microbiome stability is altered by probiotic ingestion and improved by the continuous supplementation of galactooligosaccharide.

Chenchen Ma, Sanjeev Wasti, Shi Huang, Zeng Zhang, Rajeev Mishra, Shuaiming Jiang, Zhengkai You, Yixuan Wu, Haibo Chang, Yuanyuan Wang and 5 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Gut microbes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05770726 (The Comparison of the Adjuvant Effect of Probiotics Between Delivery Via Colonoscopic Spray and Oral Administration in Patients With Clostridioides Difficile Colitis Receiving Vancomycin Treatment), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05770726 naunknown statusnot on this mapstarted 2023, after this paper: background citation

The Comparison of the Adjuvant Effect of Probiotics Between Delivery Via Colonoscopic Spray and Oral Administration in Patients With Clostridioides Difficile Colitis Receiving Vancomycin Treatment

TypeinterventionalSponsorNational Cheng-Kung University HospitalRan2023 to 2024Enrolled60ConditionsDiarrhea InfectiousArmsProbiotics administration
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Probiotic Supplementation and its Potential Benefits in Type 2 Diabetes: A Meta-analysis.Endocrine, metabolic & immune disorders drug targets · 2026
    Pooled it
  2. Review
  3. Microorganisms · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Distinct Effects ofMicroorganisms · 2025
    Article
  9. Foods (Basel, Switzerland) · 2025
    Article
  10. Review
  11. Probiotics and muscle health: the impact ofFrontiers in microbiology · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Frontiers in microbiology · 2024
    Article
  18. Article
  19. Research (Washington, D.C.) · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Chenchen MaCollege of Food Science and Engineering, Hainan University , Haikou, China.
Sanjeev WastiDepartment of Human Nutrition, Food and Animal Science, University of Hawaii , Honolulu, HI, USA.
Shi HuangSingle-Cell Center, CAS Key Laboratory of Biofuels and Shandong Key Laboratory of Energy Genetics, Qingdao Institute of BioEnergy and Bioprocess Technology, Chinese Academy of Sciences , Qingdao, China.
Zeng ZhangCollege of Food Science and Engineering, Hainan University , Haikou, China.
Rajeev MishraDepartment of Human Nutrition, Food and Animal Science, University of Hawaii , Honolulu, HI, USA.ORCID 0000-0003-1404-3477
Shuaiming JiangCollege of Food Science and Engineering, Hainan University , Haikou, China.
Zhengkai YouCollege of Food Science and Engineering, Hainan University , Haikou, China.
Yixuan WuCollege of Food Science and Engineering, Hainan University , Haikou, China.
Haibo ChangCollege of Food Science and Engineering, Hainan University , Haikou, China.
Yuanyuan WangCollege of Food Science and Engineering, Hainan University , Haikou, China.
Dongxue HuoCollege of Food Science and Engineering, Hainan University , Haikou, China.
Congfa LiCollege of Food Science and Engineering, Hainan University , Haikou, China.
Zhihong SunKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education P. R. C., Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs China, Inner Mongolia Agricultural University , Hohhot, China.
Zheng SunSingle-Cell Center, CAS Key Laboratory of Biofuels and Shandong Key Laboratory of Energy Genetics, Qingdao Institute of BioEnergy and Bioprocess Technology, Chinese Academy of Sciences , Qingdao, China.
Jiachao ZhangCollege of Food Science and Engineering, Hainan University , Haikou, China.ORCID 0000-0001-8099-6749
Hainan University · CNInner Mongolia Agricultural University · CNUniversity of Hawaii System · USChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The stable gut microbiome plays a key role in sustaining host health, while the instability of gut microbiome also has been found to be a risk factor of various metabolic diseases. At the ecological and evolutionary scales, the inevitable competition between the ingested probiotic and indigenous gut microbiome can lead to an increase in the instability. It remains largely unclear if and how exogenous prebiotic can improve the overall gut microbiome stability in probiotic consumption. In this study, we used

Indexed as

Dietary SupplementsAnimalsGastrointestinal MicrobiomeGlycoside HydrolasesLactiplantibacillus plantarumMiceMutationOligosaccharidesPrebioticsProbioticsGlycoside HydrolasesOligosaccharidesPrebioticsgalactooligosaccharide (GOS)intestinal microbiomeLactobacillus plantarum HNU082metagenomeprebioticsprobioticssingle-nucleotide polymorphism (SNP)

Identifiers

PMID32663059
PMCPMC7524268
OpenAlexW3043667256

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.