ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2020
Lower-limb venous distension reflex and orthostatic tolerance in young healthy humans.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 6 citations in OpenAlex.
- Atrial Fibrillation and Great Saphenous Vein Insufficiency: Exploration of Common Pathways in Hemodynamic Derangements and Systemic Inflammation.Reviews in cardiovascular medicine · 2026Review
- The effects of limb suction during arterial occlusion on arterial baroreflex in humans.American journal of physiology. Heart and circulatory physiology · 2025Article
- The role of peripheral venous distension reflex in regulating hemodynamics: mini review.Autonomic neuroscience : basic & clinical · 2024Review
- Sitting knee-flexion angle does not influence endothelial-dependent vasodilation in laboratory or free-living conditions.Vascular medicine (London, England) · 2024Article
- Effect of Cyclooxygenase Inhibition on Peripheral Venous Distension Reflex in Healthy Humans.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Baroreflex responses to limb venous distension in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Earlier reports suggest that limb venous distension evokes reflex increases in muscle sympathetic nerve activity (MSNA) and blood pressure (BP) (i.e., venous distension reflex). Our recent report also shows that suction of arterially occluded limb evokes venous distension reflex. We postulate that the venous distension reflex contributes to autonomic responses to orthostatic stress. In this study, we hypothesized that orthostatic tolerance would be linked to the MSNA response seen with lower limb suction. Fifteen healthy subjects were tested in the supine position. Negative pressure (-100 mmHg) was applied on an arterially occluded lower limb for 2 min. MSNA from the peroneal nerve in the limb not exposed to suction, ECG, and BP (Finometer) was recorded throughout the study. Limb occlusion without suction was used as a control trial. In a separate visit, the individual's orthostatic tolerance was assessed using a graded lower body negative pressure (LBNP) tolerance test. Mean arterial BP and MSNA (18.6 ± 1.9 to 23.6 ± 2.0 bursts/min) significantly (both
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.