Evidence map›Paper›PMID 32662975›Full record

ArticleACS chemical biology2020

An Irreversible Inhibitor to Probe the Role of

Jordan L Woehl, Seiya Kitamura, Nicholas Dillon, Zhen Han, Landon J Edgar, Victor Nizet, Dennis W Wolan

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Dihydrothiazolo ring-fused 2-pyridone antimicrobial compounds treatbioRxiv : the preprint server for biology · 2024
    Article
  5. Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jordan L Woehl
Nicholas Dillon
Zhen Han
Landon J Edgar
Victor Nizet
Scripps Research Institute · USUniversity of California San Diego · US

Funding

MOLECULAR BASIS OF VIRAL PATHOGENESIST32AI007354 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI DE LA TORRE, JUAN C. · 1989 to 2020
$5.2M
GAS Switch from Colonizing Bacterium to Invasive PathogenR01AI077780 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIZET, VICTOR · 2008 to 2019
$3.8M
C3-Dependent Intracellular Killing in Innate Immunity and Bacterial PathogenesisR01AI145325 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIZET, VICTOR, RAFFATELLU, MANUELA · 2019 to 2023
$3.1M
Expanding the chemical biological tools for the detection and regulation of human and bacterial proteasesR35GM136286 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI WOLAN, DENNIS WILLIAM · 2020 to 2020
$213k
NIAID NIH HHS R01 AI077780NIAID NIH HHS R01 AI145325NIAID NIH HHS T32 AI007354NIGMS NIH HHS R35 GM136286
6 · The paper itself

Abstract

Members of the CA class of cysteine proteases have multifaceted roles in physiology and virulence for many bacteria. Streptococcal pyrogenic exotoxin B (SpeB) is secreted by

Indexed as

Bacterial ProteinsCrystallography, X-RayCysteine ProteasesCysteine Proteinase InhibitorsDrug DesignProtein ConformationStreptococcus pyogenesStructure-Activity RelationshipVirulenceBacterial ProteinsCysteine ProteasesCysteine Proteinase Inhibitors

Identifiers

PMID32662975
PMCPMC7755099
OpenAlexW3043679126

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.