Evidence map›Paper›PMID 32662899›Full record

ArticleJournal of medical virology2021

Clinical neurophysiology and cerebrospinal liquor analysis to detect Guillain-Barré syndrome and polyneuritis cranialis in COVID-19 patients: A case series.

Paolo Manganotti, Giulia Bellavita, Laura D'Acunto, Valentina Tommasini, Martina Fabris, Arianna Sartori, Lucia Bonzi, Alex Buoite Stella, Valentina Pesavento

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 14 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 14 syntheses or guidelines pooled it, 82 citations in OpenAlex.

  1. Pooled it
  2. Neurological and Head/Eyes/Ears/Nose/Throat Manifestations of COVID-19: A Systematic Review and Meta-Analysis.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2022
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  3. COVID-19 associated cranial nerve neuropathy: A systematic review.Bosnian journal of basic medical sciences · 2022
    Pooled it
  4. Guillain Barre Syndrome as a Complication of COVID-19: A Systematic Review.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2022
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  17. Long-term effects of SARS-CoV-2 infection in patients with and without chemosensory disorders at disease onset: a psychophysical and magnetic resonance imaging exploratory study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Paolo ManganottiClinical Unit of Neurology, Department of Medicine, Surgery, and Health Sciences, Cattinara University Hospital ASUGI, University of Trieste, Trieste, Italy.ORCID 0000-0001-5305-6268
Giulia BellavitaClinical Unit of Neurology, Department of Medicine, Surgery, and Health Sciences, Cattinara University Hospital ASUGI, University of Trieste, Trieste, Italy.
Laura D'AcuntoClinical Unit of Neurology, Department of Medicine, Surgery, and Health Sciences, Cattinara University Hospital ASUGI, University of Trieste, Trieste, Italy.
Valentina TommasiniClinical Unit of Neurology, Department of Medicine, Surgery, and Health Sciences, Cattinara University Hospital ASUGI, University of Trieste, Trieste, Italy.
Martina FabrisLaboratory of Malattie Autoimmuni, SOC Istituto di Patologia Clinica, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.
Arianna SartoriClinical Unit of Neurology, Department of Medicine, Surgery, and Health Sciences, Cattinara University Hospital ASUGI, University of Trieste, Trieste, Italy.
Lucia BonziRehabilitation Unit, Department of Medicine, Surgery, and Health Sciences, Maggiore City Hospital, Trieste, Italy.
Alex Buoite StellaClinical Unit of Neurology, Department of Medicine, Surgery, and Health Sciences, Cattinara University Hospital ASUGI, University of Trieste, Trieste, Italy.ORCID 0000-0002-4871-7022
Valentina PesaventoRehabilitation Unit, Department of Medicine, Surgery, and Health Sciences, Maggiore City Hospital, Trieste, Italy.
University of Trieste · ITOspedale Maggiore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case series of five patients affected by SARS-CoV-2 who developed neurological symptoms, mainly expressing as polyradiculoneuritis and cranial polyneuritis in the 2 months of COVID-19 pandemic in a city in the northeast of Italy. A diagnosis of Guillain-Barré syndrome was made on the basis of clinical presentation, cerebrospinal fluid analysis, and electroneurography. In four of them, the therapeutic approach included the administration of intravenous immunoglobulin (0.4 g/kg for 5 days), which resulted in the improvement of neurological symptoms. Clinical neurophysiology revealed the presence of conduction block, absence of F waves, and in two cases a significant decrease in amplitude of compound motor action potential compound muscle action potential (cMAP). Four patients presented a mild facial nerve involvement limited to the muscles of the lower face, with sparing of the forehead muscles associated to ageusia. In one patient, taste assessment showed right-sided ageusia of the tongue, ipsilateral to the mild facial palsy. In three patients we observed albuminocytological dissociation in the cerebrospinal fluid, and notably, we found an increase of inflammatory mediators such as the interleukin-8. Peripheral nervous system involvement after infection with COVID-19 is possible and may include several signs that may be successfully treated with immunoglobulin therapy.

Indexed as

Nervous System Physiological PhenomenaAgedAged, 80 and overAgeusiaCOVID-19COVID-19 SerotherapyFacial ParalysisFemaleGuillain-Barre SyndromeHumansImmunization, PassiveInterleukin-8ItalyMaleMiddle AgedNeuritisCXCL8 protein, humanInterleukin-8COVID-19cranial polyneuritisimmunoglobulininterleukinspolyradiculonevritis

Identifiers

PMID32662899
PMCPMC7405169
OpenAlexW3043435390

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.