Evidence map›Paper›PMID 32662761›Full record

ArticleRadiology2020

Predicting PET Cerebrovascular Reserve with Deep Learning by Using Baseline MRI: A Pilot Investigation of a Drug-Free Brain Stress Test.

David Y T Chen, Yosuke Ishii, Audrey P Fan, Jia Guo, Moss Y Zhao, Gary K Steinberg, Greg Zaharchuk

Open access · greenAbstract read
In one paragraph

Article in Radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 28 citations in OpenAlex.

  1. Generating Synthetic MR Spectroscopic Imaging Data with Generative Adversarial Networks to Train Machine Learning Models.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
    Article
  2. Article
  3. Turning brain MRI into diagnostic PET:Medical image analysis · 2024
    Article
  4. Article
  5. Article
  6. Revascularization improves vascular hemodynamics - a study assessing cerebrovascular reserve and transit time in Moyamoya patients using MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  7. Article
  8. Article
  9. A review on AI in PET imaging.Annals of nuclear medicine · 2022
    Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

David Y T ChenFrom the Department of Radiology, The Richard M. Lucas Center for Imaging, Stanford University, 1201 Welch Rd, Stanford, CA 94305 (D.Y.T.C., A.P.F., M.Y.Z., G.Z.); Department of Medical Imaging, Taipei Medical University-Shuan-Ho Hospital, New Taipei City, Taiwan (D.Y.T.C.); Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan (D.Y.T.C.); Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan (Y.I.); Department of Bioengineering, University of California Riverside, Riverside, Calif (J.G.); and Department of Neurosurgery, Stanford University, Stanford, Calif (G.K.S.).ORCID 0000-0002-2587-2214
Yosuke IshiiFrom the Department of Radiology, The Richard M. Lucas Center for Imaging, Stanford University, 1201 Welch Rd, Stanford, CA 94305 (D.Y.T.C., A.P.F., M.Y.Z., G.Z.); Department of Medical Imaging, Taipei Medical University-Shuan-Ho Hospital, New Taipei City, Taiwan (D.Y.T.C.); Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan (D.Y.T.C.); Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan (Y.I.); Department of Bioengineering, University of California Riverside, Riverside, Calif (J.G.); and Department of Neurosurgery, Stanford University, Stanford, Calif (G.K.S.).ORCID 0000-0001-8944-6241
Audrey P FanFrom the Department of Radiology, The Richard M. Lucas Center for Imaging, Stanford University, 1201 Welch Rd, Stanford, CA 94305 (D.Y.T.C., A.P.F., M.Y.Z., G.Z.); Department of Medical Imaging, Taipei Medical University-Shuan-Ho Hospital, New Taipei City, Taiwan (D.Y.T.C.); Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan (D.Y.T.C.); Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan (Y.I.); Department of Bioengineering, University of California Riverside, Riverside, Calif (J.G.); and Department of Neurosurgery, Stanford University, Stanford, Calif (G.K.S.).ORCID 0000-0001-5850-6117
Jia GuoFrom the Department of Radiology, The Richard M. Lucas Center for Imaging, Stanford University, 1201 Welch Rd, Stanford, CA 94305 (D.Y.T.C., A.P.F., M.Y.Z., G.Z.); Department of Medical Imaging, Taipei Medical University-Shuan-Ho Hospital, New Taipei City, Taiwan (D.Y.T.C.); Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan (D.Y.T.C.); Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan (Y.I.); Department of Bioengineering, University of California Riverside, Riverside, Calif (J.G.); and Department of Neurosurgery, Stanford University, Stanford, Calif (G.K.S.).ORCID 0000-0003-3371-5857
Moss Y ZhaoFrom the Department of Radiology, The Richard M. Lucas Center for Imaging, Stanford University, 1201 Welch Rd, Stanford, CA 94305 (D.Y.T.C., A.P.F., M.Y.Z., G.Z.); Department of Medical Imaging, Taipei Medical University-Shuan-Ho Hospital, New Taipei City, Taiwan (D.Y.T.C.); Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan (D.Y.T.C.); Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan (Y.I.); Department of Bioengineering, University of California Riverside, Riverside, Calif (J.G.); and Department of Neurosurgery, Stanford University, Stanford, Calif (G.K.S.).
Gary K SteinbergFrom the Department of Radiology, The Richard M. Lucas Center for Imaging, Stanford University, 1201 Welch Rd, Stanford, CA 94305 (D.Y.T.C., A.P.F., M.Y.Z., G.Z.); Department of Medical Imaging, Taipei Medical University-Shuan-Ho Hospital, New Taipei City, Taiwan (D.Y.T.C.); Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan (D.Y.T.C.); Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan (Y.I.); Department of Bioengineering, University of California Riverside, Riverside, Calif (J.G.); and Department of Neurosurgery, Stanford University, Stanford, Calif (G.K.S.).
Greg ZaharchukFrom the Department of Radiology, The Richard M. Lucas Center for Imaging, Stanford University, 1201 Welch Rd, Stanford, CA 94305 (D.Y.T.C., A.P.F., M.Y.Z., G.Z.); Department of Medical Imaging, Taipei Medical University-Shuan-Ho Hospital, New Taipei City, Taiwan (D.Y.T.C.); Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan (D.Y.T.C.); Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan (Y.I.); Department of Bioengineering, University of California Riverside, Riverside, Calif (J.G.); and Department of Neurosurgery, Stanford University, Stanford, Calif (G.K.S.).ORCID 0000-0001-5781-8848
Taipei Medical University Hospital · TWTokyo Medical and Dental University · JPUniversity of California, Riverside · US

Funding

Cerebrovascular Reserve Imaging with Simultaneous PET/MRI Using Arterial Spin Labeling and Deep LearningR01EB025220 · NIBIB · STANFORD UNIVERSITY · PI ZAHARCHUK, GREGORY GEORGE · 2018 to 2021
$2.8M
Quantitative PET/MRI of brain oxygenation in cerebrovascular diseaseK99NS102884 · NINDS · STANFORD UNIVERSITY · PI FAN, AUDREY PEIWEN · 2018 to 2019
$170k
NIBIB NIH HHS R01 EB025220NINDS NIH HHS K99 NS102884
6 · The paper itself

Abstract

Background Cerebrovascular reserve (CVR) may be measured by using an acetazolamide test to clinically evaluate patients with cerebrovascular disease. However, acetazolamide use may be contraindicated and/or undesirable in certain clinical settings. Purpose To predict CVR images generated from acetazolamide vasodilation with a deep learning network by using only images before acetazolamide administration. Materials and Methods Simultaneous oxygen 15 (

Indexed as

Deep LearningAdolescentAdultBrainCerebrovascular CirculationFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMoyamoya DiseasePilot ProjectsPositron-Emission TomographyYoung Adult

Identifiers

PMID32662761
PMCPMC7457949
OpenAlexW3043246085

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.