Evidence map›Paper›PMID 32662710›Full record

ArticleThe Journal of international medical research2020

Pravastatin attenuates atherosclerosis after myocardial infarction by inhibiting inflammatory Ly6C

Yufei Chen, Hongqi Zhang, Liang Hu, Haiming Shi, Xiaojin Liu, Jianguo Jia, Shengjia Sun, Yang Ou, Xinping Luo, Guomin Zhou and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Targeted drug delivery systems for atherosclerosis.Journal of nanobiotechnology · 2025
    Review
  3. Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Yufei ChenDepartment of Cardiology, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-4346-6391
Hongqi ZhangDepartment of Anatomy, Histology and Embryology, Shanghai Medical College, Fudan University, Shanghai, China.
Liang HuCardiovascular Institute of Zhengzhou University, Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Haiming ShiDepartment of Cardiology, Huashan Hospital, Fudan University, Shanghai, China.
Xiaojin LiuDepartment of Cardiology, Huashan Hospital, Fudan University, Shanghai, China.
Jianguo JiaShanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Shengjia SunDepartment of Cardiology, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-4253-3046
Yang OuDepartment of Cardiology, Huashan Hospital, Fudan University, Shanghai, China.
Xinping LuoDepartment of Cardiology, Huashan Hospital, Fudan University, Shanghai, China.
Guomin ZhouDepartment of Anatomy, Histology and Embryology, Shanghai Medical College, Fudan University, Shanghai, China.
Wei ShenDepartment of Cardiology, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0003-3732-989X
Fudan University · CNShanghai Medical College of Fudan University · CNFirst Affiliated Hospital of Zhengzhou University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the protective effect of pravastatin on atherosclerotic development and inflammatory monocyte subset in atherosclerotic apolipoprotein E (ApoE)

methodsMale ApoE

resultsPravastatin improved cardiac function and reduced lesion areas. It also attenuated the supply of monocytes in spleen, especially the inflammatory Ly6C

conclusionsMI accelerated chronic atherosclerosis progress. Pravastatin suppressed atherosclerotic development and inhibited inflammatory monocytosis after MI in ApoE

Indexed as

AtherosclerosisMyocardial InfarctionPlaque, AtheroscleroticAnimalsApolipoproteins EDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutPravastatinApolipoproteins EPravastatinatherosclerosisinflammationmonocyte subsetsmonocytosismyocardial infarctionPravastatin

Identifiers

PMID32662710
PMCPMC7361503
OpenAlexW3043721436

What OpenQuestion holds

Texttitle and abstract
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.