ArticleThe Journal of international medical research2020
Non-linear relationship between gamma-glutamyl transferase and type 2 diabetes mellitus risk: secondary analysis of a prospective cohort study.
Article in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- The triglyceride to HDL‑C ratio explains part of the association between fatty liver and incident type 2 diabetes: a statistical mediation analysis of the NAGALA cohort.BMC gastroenterology · 2026Article
- Age, dyslipidemia, and gamma-glutamyl transferase are associated with diabetes in obesity: a cross-sectional study.Frontiers in clinical diabetes and healthcare · 2026Article
- Amino Acid Profile Alterations in the Mother-Fetus System in Gestational Diabetes Mellitus and Macrosomia.International journal of molecular sciences · 2025Article
- Association between serum gamma glutamyl transferase and fasting blood glucose in Chinese people: A 6-year follow-up study.Journal of diabetes investigation · 2023Article
- Cumulative Exposure to High γ-Glutamyl Transferase Level and Risk of Diabetes: A Nationwide Population-Based Study.Endocrinology and metabolism (Seoul, Korea) · 2022Article
- Gamma-glutamyl transferase to high-density lipoprotein cholesterol ratio: A valuable predictor of type 2 diabetes mellitus incidence.Frontiers in endocrinology · 2022Article
- To explore association between gamma-glutamyl transferase and type 2 diabetes using a real-world study and mendelian randomization analysis.Frontiers in endocrinology · 2022Observational
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the association between gamma-glutamyl transferase (GGT) and type 2 diabetes mellitus (T2DM) risk.
methodsThis was a secondary analysis based on a publicly available DRYAD dataset that included 15 444 study participants that received medical examinations at a single centre in Japan between 2004 and 2015. Crude, minimally-adjusted and fully-adjusted regression models were used to evaluate the relationship between GGT levels and T2DM risk.
resultsThe study participants (mean ± SD age of 43.72 ± 8.90 years; 8415 of 15 444 [54.49%] were male) were followed-up for a median of 1968 days (5.39 years). After adjusting for potential covariates, a non-linear relationship between the baseline GGT level and T2DM incidence was observed. The inflection point for T2DM risk was 10 IU/l GGT; below this point, the T2DM incidence increased by 1.18-fold per unit change in GGT. Above this point, the association between GGT and the incidence rate of T2DM became nonsignificant.
conclusionBaseline GGT exhibited a non-linear association with T2DM incidence. Elevated GGT levels should be incorporated into routine screening for individuals at high risk of T2DM, allowing for early intervention targeting GGT to potentially reduce T2DM-related morbidity.
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