Evidence map›Paper›PMID 32662593›Full record

ArticleNMR in biomedicine2020

Acute-stage MRI cerebral oxygen consumption biomarkers predict 24-hour neurological outcome in a rat cardiac arrest model.

Zhiliang Wei, Qihong Wang, Hiren R Modi, Sung-Min Cho, Romergryko Geocadin, Nitish V Thakor, Hanzhang Lu

Open access · greenAbstract read
In one paragraph

Article in NMR in biomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Zhiliang WeiDepartment of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Qihong WangDepartment of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Hiren R ModiDepartment of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Sung-Min ChoDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Romergryko GeocadinDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Nitish V ThakorDepartment of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Hanzhang LuDepartment of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

TR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2012 to 2020
$13.1M
Consequences of Cardiac Arrest: Brain InjuryR01HL071568 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI GEOCADIN, ROMERGRYKO, THAKOR, NITISH VYOMESH · 2003 to 2022
$8.4M
1/2 ICECAP: Influence of Cooling duration on Efficacy in Cardiac Arrest PatientsUG3HL145269 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GEOCADIN, ROMERGRYKO, MEURER, WILLIAM JOSEPH · 2019 to 2019
$4.4M
Normalized functional MRI in human brain disordersR01MH084021 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI LU, HANZHANG · 2008 to 2017
$3.6M
Brain oxygen consumption as an MRI biomarker of neurodegeneration in a model of Alzheimer?s diseaseR21AG058413 · NIA · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2018 to 2019
$465k
NHLBI NIH HHS R01 HL071568NHLBI NIH HHS UG3 HL145269NIA NIH HHS R21 AG058413NIBIB NIH HHS P41 EB015909NIMH NIH HHS R01 MH084021
6 · The paper itself

Abstract

Brain injury following cardiac arrest (CA) is thought to be caused by a sudden loss of blood flow resulting in disruption in oxygen delivery, neural function and metabolism. However, temporal trajectories of the brain's physiology in the first few hours following CA have not been fully characterized. Furthermore, the extent to which these early measures can predict future neurological outcomes has not been determined. The present study sought to perform dynamic measurements of cerebral blood flow (CBF), oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO

Indexed as

Magnetic Resonance ImagingAnimalsBiomarkersBrainDisease Models, AnimalFemaleHeart ArrestOxygen ConsumptionPhantoms, ImagingRatsSignal Processing, Computer-AssistedBiomarkerscardiac arrestcerebral blood flowcerebral metabolic rate of oxygenMRIneurologic deficit scoreoxygen consumptionphase contrastTRUST

Identifiers

PMID32662593
PMCPMC7541582
OpenAlexW3043226132

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.