Evidence map›Paper›PMID 32662552›Full record

ArticleJournal of neuroendocrinology2020

Binding affinities of oxytocin, vasopressin and Manning compound at oxytocin and V1a receptors in male Syrian hamster brains.

Jack H Taylor, Katharine E McCann, Amy P Ross, H Elliott Albers

Open access · greenAbstract read
In one paragraph

Article in Journal of neuroendocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  5. Nebulized vasopressin penetrates CSF and improves social cognition without inducing aggression in a rhesus monkey model of autism.Proceedings of the National Academy of Sciences of the United States of America · 2024
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jack H TaylorNeuroscience Institute, Georgia State University, Atlanta, Georgia, USA.ORCID 0000-0002-4334-1468
Katharine E McCannNeuroscience Institute, Georgia State University, Atlanta, Georgia, USA.
Amy P RossNeuroscience Institute, Georgia State University, Atlanta, Georgia, USA.
H Elliott AlbersNeuroscience Institute, Georgia State University, Atlanta, Georgia, USA.
Georgia State University · US

Funding

Sex Differences in the Social BrainR01MH110212 · NIMH · GEORGIA STATE UNIVERSITY · PI ALBERS, H. ELLIOTT, MICHOPOULOS, VASILIKI · 2016 to 2020
$3.3M
NIMH NIH HHS MH110212NIMH NIH HHS R01 MH110212
6 · The paper itself

Abstract

Oxytocin (OT) and arginine vasopressin (AVP), as well as synthetic ligands targeting their receptors (OTR, V1aR), are used in a wide variety of research contexts, although their pharmacological properties are determined in only a few species. Syrian hamsters (Mesocricetus auratus) have a long history of use as a behavioural and biomedical model for the study of OT and AVP and, more recently, hamsters have been used to investigate behavioural consequences of OT-mediated activation of V1aR. We aimed to determine the binding affinities of OT, AVP and the selective V1aR antagonist, Manning compound, for OTR and V1aR in hamster brains. We performed saturation binding assays to determine the Kd values for the selective OTR and V1aR radioligands, [

Indexed as

AnimalsArginine VasopressinBinding, CompetitiveBrainCricetinaeHumansMaleMesocricetusOxytocinProtein BindingRatsReceptors, G-Protein-CoupledReceptors, OxytocinReceptors, VasopressinArginine VasopressinOxytocinReceptors, G-Protein-CoupledReceptors, OxytocinReceptors, Vasopressinvasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine-binding affinitycomparativeGPCRG protein-coupled receptorradioligand binding assay

Identifiers

PMID32662552
PMCPMC7485222
OpenAlexW3034983876

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.