Evidence map›Paper›PMID 32662547›Full record

Observational studyJournal of clinical pharmacy and therapeutics2020

Pharmacogenomics in kidney transplant recipients and potential for integration into practice.

Tam T Nguyen, Rachael A Pearson, Moataz E Mohamed, David P Schladt, Danielle Berglund, Zachary Rivers, Debra J Skaar, Baolin Wu, Weihua Guan, Jessica van Setten and 8 more

Registry-linked trialOpen access · greenAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of clinical pharmacy and therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01714440 (Genomics of Kidney Transplantation), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01714440 completednot on this map

Genomics of Kidney Transplantation

TypeobservationalSponsorNational Institute of Allergy and Infectious Diseases (NIAID)Ran2012 to 2017Enrolled1,552ConditionsKidneyTransplant Recipients, Simultaneous Kidney/Pancreas Recipients, Kidney Transplant Donor
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Monogenic Kidney Diseases in Kidney Transplantation.Kidney international reports · 2024
    Review
  6. [Pharmacogenetic testing improves treatment responses in patients with PLA2R-related membranous nephropathy].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 3 countries.

Tam T NguyenCollege of Pharmacy, University of Minnesota, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0002-1191-9659
Rachael A PearsonCollege of Pharmacy, University of Minnesota, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0002-5102-661X
Moataz E MohamedDepartment of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0002-7266-9980
David P SchladtChronic Disease Research Group, Minneapolis Medical Research Foundation, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0002-3793-5745
Danielle BerglundComplex Care Core Analytics, Fairview University of Minnesota, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0003-1935-7301
Zachary RiversSocial and Administrative Pharmacy, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0002-4957-4908
Debra J SkaarDepartment of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0002-4902-9168
Baolin WuDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0001-6676-0422
Weihua GuanDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0002-0956-9821
Jessica van SettenDepartment of Cardiology, University Medical Center Utrecht, University of Utrecht, Utrecht, Netherlands.ORCID https://orcid.org/0000-0002-4934-7510
Brendan J KeatingPenn Transplant Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID https://orcid.org/0000-0002-3320-3723
Casey DorrMinneapolis Medical Research Foundation and Division of Nephrology, Hennepin Healthcare, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0002-6108-280X
Rory P RemmelDepartment of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0002-1532-1726
Arthur J MatasDepartment of Surgery, School of Medicine, University of Minnesota, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0001-9957-639X
Roslyn B MannonDepartment of Nephrology, School of Medicine, University of Nebraska, Omaha, NE, USA.ORCID https://orcid.org/0000-0003-1776-3680
Ajay K IsraniDivision of Nephrology, Hennepin Healthcare, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0002-7607-0430
William S OettingDepartment of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0002-1076-0711
Pamala A JacobsonDepartment of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0002-4145-7045
University of Minnesota · USHennepin Healthcare Research Institute · USOrthopaedic Research Foundation · USUniversity of Nebraska at Omaha · USUniversity of Pennsylvania · USUtrecht University · NL

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
Pharmacogenomics of Immune Suppressants in Kidney TransplantationU19AI070119 · NIAID · UNIVERSITY OF MINNESOTA · PI MATAS, ARTHUR J · 2006 to 2016
$17.1M
Long-term Deterioration of Kidney Allograft FunctionU01AI058013 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MATAS, ARTHUR J · 2005 to 2010
$10.2M
NRSA Training CoreTL1TR002493 · NCATS · UNIVERSITY OF MINNESOTA · PI FULKERSON, JAYNE ALLYN · 2018 to 2022
$3.1M
Melendy Student Research Scholarships, University of Minnesota, College of PharmacyNational Institute of Allergy and Infectious Disease and U01-AI058013National Institute of Allergy and Infectious Disease U19-AI070119NCATS NIH HHS TL1 TR002493NCATS NIH HHS UL1 TR002494NIAID NIH HHS U01 AI058013NIAID NIH HHS U19 AI070119
6 · The paper itself

Abstract

WHAT IS KNOWN AND

objectivePharmacogenomic biomarkers are now used in many clinical care settings and represent one of the successes of precision medicine. Genetic variants are associated with pharmacokinetic and pharmacodynamic changes leading to medication adverse effects and changes in clinical response. Actionable pharmacogenomic variants are common in transplant recipients and have implications for medications used in transplant, but yet are not broadly incorporated into practice.

methodsFrom the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group guidelines, and PharmGKB databases, 12 pharmacogenomic genes with 30 variants were selected and used to create diplotypes and actionable pharmacogenomic phenotypes. A total of 853 kidney allograft recipients who had genomic information available from a genome-wide association study were included.

resultsEach recipient had at least one actionable pharmacogenomic diplotype/phenotype, whereas the majority (58%) had three or four actionable diplotypes/phenotypes and 17.4% had five or more among the 12 genes. The participants carried actionable diplotypes/phenotypes for multiple medications, including tacrolimus, azathioprine, clopidogrel, warfarin, simvastatin, voriconazole, antidepressants and proton-pump inhibitors. WHAT IS NEW AND

conclusionPharmacogenomic variants are common in transplant recipients, and transplant recipients receive medications that have actionable variants. CLINICAL TRIAL: Genomics of Transplantation, clinicaltrials.gov (NCT01714440).

Indexed as

Pharmacogenomic VariantsAdultFemaleGenome-Wide Association StudyHumansKidney TransplantationMaleMiddle AgedPharmacogeneticsPhenotypeProspective Studiesclinical pharmacykidney transplantationpharmacogeneticspharmacogenomics

Identifiers

PMID32662547
PMCPMC7719579
OpenAlexW3043549761

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.