Evidence map›Paper›PMID 32662519›Full record

ArticleBritish journal of pharmacology2020

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research.

Nathalie Percie du Sert, Viki Hurst, Amrita Ahluwalia, Sabina Alam, Marc T Avey, Monya Baker, William J Browne, Alejandra Clark, Innes C Cuthill, Ulrich Dirnagl and 18 more

Abstract read
In one paragraph

Article in British journal of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 484 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
484citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

484 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Tooth regeneration in animals. A systematic review.Medicina oral, patologia oral y cirugia bucal · 2025
    Pooled it
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  13. Sex-specific role of microglia in ΔNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  14. Article
  15. Chlorogenic acid attenuates TBI-induced neuroinflammation by suppressing cGAS-STING signaling.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
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424 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Nathalie Percie du SertNC3Rs, London, UK.
Viki HurstNC3Rs, London, UK.
Amrita AhluwaliaThe William Harvey Research Institute, London, UK.
Sabina AlamTaylor & Francis Group, London, UK.
Marc T AveyHealth Science Practice, ICF, Durham, North Carolina, USA.
Monya BakerNature, San Francisco, California, USA.
William J BrowneSchool of Education, University of Bristol, Bristol, UK.
Alejandra ClarkPLOS ONE, Cambridge, UK.
Innes C CuthillSchool of Biological Sciences, University of Bristol, Bristol, UK.
Ulrich DirnaglQUEST Center for Transforming Biomedical Research, Berlin Institute of Health & Department of Experimental Neurology, Charite Universitätsmedizin Berlin, Berlin, Germany.
Michael EmersonNational Heart and Lung Institute, Imperial College London, London, UK.
Paul GarnerCentre for Evidence Synthesis in Global Health, Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, UK.
Stephen T HolgateClinical and Experimental Sciences, University of Southampton, Southampton, UK.
David W HowellsTasmanian School of Medicine, University of Tasmania, Hobart, Australia.
Natasha A KarpData Sciences & Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
Stanley E LazicPrioris.ai Inc, Ottawa, Canada.
Katie LidsterNC3Rs, London, UK.
Catriona J MacCallumHindawi Ltd, London, UK.
Malcolm MacleodUniversity of Edinburgh, Edinburgh, UK.
Esther J PearlNC3Rs, London, UK.
Ole H PetersenAcademia Europaea Knowledge Hub, Cardiff University, Cardiff, UK.
Frances RawleMedical Research Council, London, UK.
Penny ReynoldsStatistics in Anesthesiology Research (STAR) Core & Research Assistant Professor, Department of Anesthesiology, College of Medicine, University of Florida, Gainesville, Florida, USA.
Kieron RooneyDiscipline of Exercise and Sport Science, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Emily S SenaUniversity of Edinburgh, Edinburgh, UK.
Shai D SilberbergNational Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.
Thomas StecklerJanssen Pharmaceutica NV, Beerse, Belgium.
Hanno WürbelVeterinary Public Health Institute, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the reporting of animal research. They consist of a checklist of information to include in publications describing in vivo experiments to enable others to scrutinise the work adequately, evaluate its methodological rigour, and reproduce the methods and results. Despite considerable levels of endorsement by funders and journals over the years, adherence to the guidelines has been inconsistent, and the anticipated improvements in the quality of reporting in animal research publications have not been achieved. Here, we introduce ARRIVE 2.0. The guidelines have been updated and information reorganised to facilitate their use in practice. We used a Delphi exercise to prioritise and divide the items of the guidelines into 2 sets, the "ARRIVE Essential 10," which constitutes the minimum requirement, and the "Recommended Set," which describes the research context. This division facilitates improved reporting of animal research by supporting a stepwise approach to implementation. This helps journal editors and reviewers verify that the most important items are being reported in manuscripts. We have also developed the accompanying Explanation and Elaboration (E&E) document, which serves (1) to explain the rationale behind each item in the guidelines, (2) to clarify key concepts, and (3) to provide illustrative examples. We aim, through these changes, to help ensure that researchers, reviewers, and journal editors are better equipped to improve the rigour and transparency of the scientific process and thus reproducibility.

Indexed as

Animal ExperimentationAnimalsChecklistReproducibility of ResultsResearch DesignResearch Report

Identifiers

PMID32662519
PMCPMC7393194

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.