Evidence map›Paper›PMID 32662457›Full record

ArticlePhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2020

Photodynamic treatment of melanoma cells using aza-dipyrromethenes as photosensitizers.

Kelly A D F Castro, Letícia D Costa, Samuel Guieu, Juliana C Biazzotto, Maria Graça P M S da Neves, M Amparo F Faustino, Roberto S da Silva, Augusto C Tomé

Abstract read
PubMed Publisher
In one paragraph

Article in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kelly A D F CastroDepartment of Physics and Chemistry, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, SP, Brazil. kellycastro@ua.pt.
Letícia D CostaLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Portugal.
Samuel GuieuLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Portugal.
Juliana C BiazzottoDepartment of Physics and Chemistry, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, SP, Brazil.
Maria Graça P M S da NevesLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Portugal.
M Amparo F FaustinoLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Portugal.
Roberto S da SilvaDepartment of Physics and Chemistry, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, SP, Brazil.
Augusto C ToméLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we report for the first time the use of four aza-dipyrromethenes (ADPMs) as photosensitizers for cancer PDT. The synthesis and characterization of the ADPMs and their photodynamic action against B16F10 melanoma cells were assessed. ADPM 2 is the best singlet oxygen generator and the most phototoxic (at 2.5 μM) towards B16F10 cells.

Indexed as

PhotochemotherapyAnimalsAntineoplastic AgentsAza CompoundsCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorMelanomaMiceMolecular StructurePhotosensitizing AgentsPorphobilinogenStructure-Activity RelationshipTumor Cells, CulturedAntineoplastic AgentsAza CompoundsdipyrromethenePhotosensitizing AgentsPorphobilinogen

Identifiers

PMID32662457

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.