ArticleReproductive sciences (Thousand Oaks, Calif.)2021
Inhibitory KIR2DL2 Gene: Risk for Deep Endometriosis in Euro-descendants.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Endometriosis: An Immunologist's Perspective.International journal of molecular sciences · 2025Review
- Killer Cell Immunoglobulin-like Receptor Genotypes and Reproductive Outcomes in a Group of Infertile Women: A Romanian Study.Diagnostics (Basel, Switzerland) · 2023Article
- Killer cell immunoglobulin-like receptor (KIR) genes and their HLA ligands in a Brazilian population.Innate immunity · 2023Article
- KIR-HLA gene diversities and susceptibility to lung cancer.Scientific reports · 2022Article
- Lack of association of the KIR and HLA class I ligands with ZIKV infection in south and southeast of Brazil.Memorias do Instituto Oswaldo Cruz · 2022Article
- Uterine Natural Killer Cells: A Rising Star in Human Pregnancy Regulation.Frontiers in immunology · 2022Review
- Current Knowledge on Endometriosis Etiology: A Systematic Review of Literature.International journal of women's health · 2021Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endometriosis (EDT) is an inflammatory disease characterized by implantation/growth of endometrial tissue, glands, and/or stroma, outside the uterus. Reduced NK cell cytotoxic activity has been implicated in its pathogenesis, together with other immunologic alterations. We investigated the influence of KIR gene polymorphisms and their HLA ligand combinations in deep endometriosis (DE) susceptibility. One hundred sixty women with a histological diagnosis of DE and 202 control women without the disease, who underwent laparoscopy, were enrolled. The DE group was subdivided into initial (I/II; n = 60) and advanced stages (III/IV, n = 100). KIR and HLA class I gene polymorphisms were typed by PCR-SSP and sequence-based-typing (SBT), respectively. We observed a significant association of KIR2DL2, an inhibitory gene of B haplotype, conferring risk for DE in Euro-descendants. Positive associations of Bx haplotype and centromeric AB segments were also found. However, no association with KIR-HLA ligand combination was observed. Our data suggest KIR2DL2 gene to be a relevant factor favoring NK inhibition in DE in Euro-descendants, contributing to the defective NK cytotoxic activity and impaired clearance of ectopic endometrial cells in the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.