ArticleMagma (New York, N.Y.)2021
Altered spontaneous brain activity in essential tremor with and without resting tremor: a resting-state fMRI study.
Article in Magma (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI.NeuroImage. Clinical · 2023Pooled it
- Abnormalities of intrinsic brain activity in essential tremor: A meta-analysis of resting-state functional imaging.Human brain mapping · 2021Pooled it
- Imaging the Pathophysiology of Essential Tremor-A Systematic Review.Frontiers in neurology · 2021Pooled it
- Thalamic and Visual Network Dysfunction Relates to Tremor Response in Thalamic Deep Brain Stimulation.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Article
- Dynamic functional changes upon thalamotomy in essential tremor depend on baseline brain morphometry.Scientific reports · 2024Article
- Combined cortical thickness and blink reflex recovery cycle to differentiate essential tremor with and without resting tremor.Frontiers in neurology · 2024Article
- Mapping Pharmacologically Evoked Neurovascular Activation and Its Suppression in a Rat Model of Tremor Using Functional Ultrasound: A Feasibility Study.Sensors (Basel, Switzerland) · 2023Article
- Cortical involvement in essential tremor with and without rest tremor: a machine learning study.Journal of neurology · 2023Article
- Using histogram analysis of the intrinsic brain activity mapping to identify essential tremor.Frontiers in neurology · 2023Article
- Exploring the heterogeneous morphometric data in essential tremor with probabilistic modelling.NeuroImage. Clinical · 2023Article
- Cerebellar voxel-based morphometry in essential tremor.Journal of neurology · 2022Article
- Essential tremor plus rest tremor: current concepts and controversies.Journal of neural transmission (Vienna, Austria : 1996) · 2022Review
- The White Matter Functional Abnormalities in Patients with Transient Ischemic Attack: A Reinforcement Learning Approach.Neural plasticity · 2022Article
- Disrupted Brain Functional Network Topology in Essential Tremor Patients With Poor Sleep Quality.Frontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesEssential tremor with resting tremor (rET) often exhibits severer clinical features and more extensive functional impairment than essential tremor without resting tremor (ETwr). However, the pathophysiology of rET is still unclear. This study aims to use resting-state functional magnetic resonance imaging (rs-fMRI) to explore the alterations of brain activity between the drug-naïve patients of rET and ETwr.
methodsWe recruited 19 patients with rET, 31 patients with ETwr and 25 healthy controls (HCs) to undergo a 3.0-T rs-fMRI examination. The differences of regional brain spontaneous activity between the rET, ETwr and HCs, as well as between total ET (rET + ETwr) and HCs were measured by amplitude of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF). The relationships between the altered brain measurements and the clinical scores were analyzed.
resultsCompared with HCs, both ET subgroups showed significantly decreased ALFF or fALFF values in the basal ganglia, inferior orbitofrontal gyrus and insula. The rET group specifically showed decreased ALFF values in the hippocampus and motor cortices, while the ETwr group specifically evidenced increased ALFF and fALFF values in the cerebellum. DISCUSSION: Regional spontaneous activity in rET and ETwr share common changes and have differences, which may suggest that the functional activities in the limbic system and cerebellum are different between the two subtypes. Improved insights into rET and ETwr subtypes and the different brain spontaneous activity will be valuable for improving our understanding of the pathophysiology of the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.