Evidence map›Paper›PMID 32661825›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2021

Noncoding RNAs as potential biomarkers for DIPG diagnosis and prognosis: XIST and XIST-210 involvement.

M Á Velázquez-Flores, J M Rodríguez-Corona, J E López-Aguilar, G Siordia-Reyes, G Ramírez-Reyes, G Sánchez-Rodríguez, R Ruiz Esparza-Garrido

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In one paragraph

Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Biological Function of Long Non-coding RNA (LncRNA) Xist.Frontiers in cell and developmental biology · 2021
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

M Á Velázquez-FloresNon-coding RNAs Laboratory, Medical Research Unit in Human Genetics, Children's Hospital "Dr. Silvestre Frenk Freund", National Medical Center XXI Century, Mexican Institute of Social Security (Instituto Mexicano del Seguro Social, IMSS), 06720, Mexico City, CDMX, Mexico.ORCID http://orcid.org/0000-0002-9442-6058
J M Rodríguez-CoronaTechnological Institute of Ciudad Victoria, National Technological Institute of Mexico, 87010, Ciudad Victoria, Tamaulipas, Mexico.
J E López-AguilarMedical Chief of the Children's Hospital "Dr. Silvestre Frenk Freund", National Medical Center XXI Century, Mexican Institute of Social Security (Instituto Mexicano del Seguro Social, IMSS), 06720, Mexico City, CDMX, Mexico.
G Siordia-ReyesPathology Department, Children's Hospital "Dr. Silvestre Frenk Freund", National Medical Center XXI Century, Mexican Institute of Social Security (Instituto Mexicano del Seguro Social, IMSS), 06720, Mexico City, CDMX, Mexico.
G Ramírez-ReyesNeurosurgery Department, Children's Hospital "Dr. Silvestre Frenk Freund", National Medical Center XXI Century, Mexican Institute of Social Security (Instituto Mexicano del Seguro Social, IMSS), 06720, Mexico City, CDMX, Mexico.
G Sánchez-RodríguezNeurosurgery Department, Children's Hospital "Dr. Silvestre Frenk Freund", National Medical Center XXI Century, Mexican Institute of Social Security (Instituto Mexicano del Seguro Social, IMSS), 06720, Mexico City, CDMX, Mexico.
R Ruiz Esparza-GarridoCatedrática CONACyT, Non-coding RNAs Laboratory, Medical Research Unit in Human Genetics, Children's Hospital "Dr. Silvestre Frenk Freund", National Medical Center XXI Century, Mexican Institute of Social Security (Instituto Mexicano del Seguro Social, IMSS) 06720 Mexico City CDMX Mexico, Av. Cuauhtémoc 330, Doctores, 06720, Mexico City, CDMX, Mexico. rruizes@conacyt.mx.ORCID http://orcid.org/0000-0003-2580-0525
Mexican Social Security Institute · MXTecnológico Nacional de México · MX

Funding

Instituto Mexicano del Seguro Social FIS/IMSS/PROT/G17/1673
6 · The paper itself

Abstract

purposeDiffuse intrinsic pontine gliomas (DIPGs) are the most fatal primary brainstem tumors in pediatric patients. The identification of new molecular features, mediating their formation and progression, as non-coding RNAs (ncRNAs), would be of great importance for the development of effective treatments.

methodsWe analyzed the DIPGs transcriptome with the HTA2.0 array and it was compared with pediatric non-brainstem astrocytoma expression profiles (GSE72269).

resultsMore than 50% of the differentially expressed transcripts were ncRNAs and based on this, we proposed a DIPGs ncRNA signature. LncRNAs XIST and XIST-210, and the HBII-52 and HBII-85 snoRNA clusters were markedly downregulated in DIPGs. qPCR assays demonstrated XIST downregulation in all non-brainstem astrocytomas, in a gender, age, and brain location-independent manner, as well as in DIPGs affecting boys; however, DIPGs affecting girls showed both downregulation and upregulation of XIST. Girls' with longer survival positively correlated with XIST expression.

conclusionsThe involvement of ncRNAs in DIPGs is imminent and their expression profile is useful to differentiate them from non-neoplastic tissues and non-brain stem astrocytomas, which suggests their potential use as DIPG biomarkers. In fact, XIST and XIST-210 are potential DIPG prognostic biomarkers.

Indexed as

TranscriptomeAdolescentAge FactorsAlternative SplicingAstrocytomaBiomarkers, TumorBrain NeoplasmsBrain Stem NeoplasmsChildChild, PreschoolDatabases, GeneticDiffuse Intrinsic Pontine GliomaDown-RegulationFemaleHumansInfantBiomarkers, TumorMicroRNAsRNA, Long NoncodingRNA, Small NucleolarRNA, UntranslatedSNORD115 RNA, humanXIST non-coding RNAAstrocytomaDiffuse intrinsic pontine gliomaslncRNAsnoRNAsXIST

Identifiers

PMID32661825
OpenAlexW3042251002

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.