Evidence map›Paper›PMID 32661792›Full record

ReviewCurrent hypertension reports2020

Brain Angiotensin Type-1 and Type-2 Receptors in Physiological and Hypertensive Conditions: Focus on Neuroinflammation.

Khalid Elsaafien, Annette D de Kloet, Eric G Krause, Colin Sumners

Open access · greenAbstract readReview
In one paragraph

Review in Current hypertension reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Review
  3. Brain and hypertension: from sympathetic outflow to brain-focused blood pressure management.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. The ATMolecules (Basel, Switzerland) · 2023
    Review
  13. Review
  14. Article
  15. Review
  16. The Angiotensin ATPharmacological reviews · 2022
    Review
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Khalid ElsaafienDepartment of Pharmacodynamics, University of Florida College of Pharmacy, Gainesville, FL, USA.
Annette D de KloetDepartment of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, FL, USA.
Eric G KrauseDepartment of Pharmacodynamics, University of Florida College of Pharmacy, Gainesville, FL, USA.
Colin SumnersDepartment of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, FL, USA. csumners@ufl.edu.ORCID 0000-0002-9689-2255
University of Florida · US

Funding

Interrogating stress-relieving neural circuits to alleviate cardiovascular diseaseR35HL150750 · NHLBI · UNIVERSITY OF FLORIDA · PI Eric Gerald Krause · 2020 to 2026
$5.9M
Neurons expressing angiotensin type 2 receptors in the NTS as an access point for cardiovascular control.R01HL136595 · NHLBI · UNIVERSITY OF FLORIDA · PI COLIN SUMNERS, Annette Diane de Kloet · 2018 to 2026
$4.8M
Paraventricular nucleus regulatory mechanisms in stress and hypertensionR01HL093186 · NHLBI · UNIVERSITY OF FLORIDA · PI SCHEUER, DEBORAH A, SUMNERS, COLIN · 2009 to 2013
$2.0M
Interrogating distinct angiotensin type-1 and type-2 receptor containing brain circuits to understand and alleviate hypertensionR01HL145028 · NHLBI · UNIVERSITY OF FLORIDA · PI DE KLOET, ANNETTE DIANE · 2019 to 2023
$1.9M
Targeting brain angiotensin signaling to discern and alleviate stress-related disease.R01HL139868 · NHLBI · UNIVERSITY OF FLORIDA · PI KRAUSE, ERIC GERALD · 2018 to 2019
$763k
Novel role of central AT2R in blood pressure regulationR00HL125805 · NHLBI · UNIVERSITY OF FLORIDA · PI DE KLOET, ANNETTE DIANE · 2016 to 2018
$746k
NHLBI NIH HHS R00 HL125805NHLBI NIH HHS R01 HL093186NHLBI NIH HHS R01 HL136595NHLBI NIH HHS R01 HL139868NHLBI NIH HHS R01 HL145028NHLBI NIH HHS R35 HL150750
6 · The paper itself

Abstract

purpose of reviewTo review recent data that suggest opposing effects of brain angiotensin type-1 (AT RECENT

findingsThe renin-angiotensin system (RAS) plays an important role in regulating cardiovascular physiology. This includes brain AT

Indexed as

HypertensionReceptor, Angiotensin, Type 2Angiotensin IBrainHumansReceptor, Angiotensin, Type 1Receptors, AngiotensinAngiotensin IReceptor, Angiotensin, Type 1Receptor, Angiotensin, Type 2Receptors, AngiotensinAT1RAT2RBrain angiotensin receptorsHypertensionMicrogliaNeuroinflammation

Identifiers

PMID32661792
PMCPMC7780348
OpenAlexW3043124198

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.