ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2021
Efficacy and safety of intraventricular fibrinolytic therapy for post-intraventricular hemorrhagic hydrocephalus in extreme low birth weight infants: a preliminary clinical study.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Impact of blood product removal versus temporary cerebrospinal fluid diversion on permanent shunting rates in posthemorrhagic hydrocephalus of prematurity: a comparative meta-analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Pooled it
- The role of blood product removal in intraventricular hemorrhage of prematurity: a meta-analysis of the clinical evidence.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Pooled it
- Advances in temporizing treatment strategies and associated complications for posthemorrhagic hydrocephalus in preterm infants.Frontiers in pediatrics · 2026Review
- Continuous Ventricular Irrigation for Intraventricular Hemorrhage.Current neurology and neuroscience reports · 2025Review
- Fibrinolytic (Thrombolytic) Therapy for Post Intraventricular Hemorrhagic Hydrocephalus in Preterm Infants.Journal of Korean Neurosurgical Society · 2023Article
- Perspectives : Understanding the Pathophysiology of Intraventricular Hemorrhage in Preterm Infants and Considering of the Future Direction for Treatment.Journal of Korean Neurosurgical Society · 2023Article
- Temporary Surgical Management of Intraventricular Hemorrhage in Premature Infants.Journal of Korean Neurosurgical Society · 2023Article
- Permanent Surgical Treatment for Posthemorrhagic Hydrocephalus in Preterm Infants.Journal of Korean Neurosurgical Society · 2023Article
- Ultrasonic Diagnosis and Management of Posthemorrhagic Ventricular Dilatation in Premature Infants: A Narrative Review.Journal of clinical medicine · 2022Review
- Treatment Strategies and Challenges to Avoid Cerebrospinal Fluid Shunting for Pediatric Hydrocephalus.Neurologia medico-chirurgica · 2022Review
- Ultrasound-assisted neuroendoscopic lavage for intraventricular hemorrhage in a newborn: illustrative case.Journal of neurosurgery. Case lessons · 2021Article
- Germinal Matrix-Intraventricular Hemorrhage: A Tale of Preterm Infants.International journal of pediatrics · 2021Review
- Management of Post-hemorrhagic Ventricular Dilatation in the Infant Born Preterm.The Journal of pediatrics · 2020Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the efficacy and safety of our unique therapy for treating post-intraventricular hemorrhagic hydrocephalus (PIVHH) in low birth weight infants (LBWls) through an early stage fibrinolytic therapeutic strategy involving urokinase (UK) injection into the lateral ventricle, called the "Ventricular Lavage (VL) therapy."
methodsOverall, 43 consecutive infants with PIVHH were included. Most were extremely LBWIs (n = 39). Other cases included very LBWIs (n = 2) and full-term infants (n = 2). VL therapy involved continuous external ventricular drainage (EVD) management using a very fine catheter and intermittent slow injection of 6000 IU of UK every 3-6 h to actively dissolve hematomas.
resultsEarly EVD management (within 3 weeks of IVH onset) was performed in 25 infants, with combination VL therapy in 21 infants. Five initiated late EVD management (≥ 3 weeks after IVH onset); the remaining 13 were treated conservatively for several weeks, delaying surgical intervention. Eighteen of 21 (86%) infants who received VL therapy did not require permanent shunt surgery. There were no serious complications, including the absence of secondary hemorrhage and infection. Two-thirds of the infants treated in the late stages required permanent shunt, and various shunt-related complications frequently occurred. A good outcome occurred in 13/17 infants in the early treatment group, despite most subjects having an IVH grade IV, and in 6/15 in the late treatment group.
conclusionsPermanent shunt surgery needs were dramatically reduced following early VL therapy, and functional outcomes were favorable. VL therapy might be a promising strategy that could lead to the development of new treatments for PIVHH.
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