Evidence map›Paper›PMID 32661619›Full record

ArticleInternational urology and nephrology2020

The protective function of miR-378 in the ischemia-reperfusion injury during renal transplantation and subsequent interstitial fibrosis of the renal allograft.

Lie Xiong, ShouNing Ding, Tie Yang

Abstract read
PubMed Publisher
In one paragraph

Article in International urology and nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lie XiongDepartment of Kidney Transplant, Yiyang Central Hospital, No.118 Kangfu North Road, Yiyang, 413000, Hunan, China. liexiong_12@163.com.ORCID http://orcid.org/0000-0003-2042-6722
ShouNing DingDepartment of Kidney Transplant, Yiyang Central Hospital, No.118 Kangfu North Road, Yiyang, 413000, Hunan, China.
Tie YangDepartment of Kidney Transplant, Yiyang Central Hospital, No.118 Kangfu North Road, Yiyang, 413000, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Survival time of kidney transplant patients is primarily threatened by chronic allograft dysfunction (CAD), whose typical feature is interstitial fibrosis and tubular atrophy (IF/TA). CAD could be caused by ischemia-reperfusion injury (IRI) during renal transplantation. MiR-378 is correlated with multiple kidney diseases and implicated in CAD. To clarify the underlying mechanism of miR-378 on renal allograft, we utilize renal unilateral IRI mice and H/R NRK52E cells. To evaluate the acute tubular damage, we determined the apoptotic rate by TUNEL assay and examined mice kidney sections of H&E staining 1 day after IRI. To assess the chronic renal interstitial inflammation and fibrosis, we detected the infiltration rates of CD45R

Indexed as

Intraoperative ComplicationsKidney TransplantationReperfusion InjuryAdultAnimalsFemaleFibrosisHumansKidneyMaleMiceMice, Inbred C57BLMicroRNAsMiddle AgedPostoperative ComplicationsProtective FactorsMicroRNAsMIRN378 microRNA, humanMIRN378 microRNA, mouseInterstitial fibrosisIschemia–reperfusion injuryKidney transplantationmiR-378

Identifiers

PMID32661619

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.