ReviewInternational journal of legal medicine2020
Epigenetic clocks may come out of rhythm-implications for the estimation of chronological age in forensic casework.
Review in International journal of legal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The trial behind it
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Who cites it
14 citing papers in PubMed.
- DNA methylation-based biomarkers of aging were slowed down in a two-year diet and physical activity intervention trial: the DAMA study.Aging cell · 2021Trial
- Differential expression of long non-coding RNAs can effectively distinguish monozygotic twins.International journal of legal medicine · 2026Article
- Past, Present and Future Perspectives of Forensic Genetics.Biomolecules · 2025Review
- Molecular age prediction using skull bone samples from individuals with and without signs of decomposition: a multivariate approach combining analysis of posttranslational protein modifications and DNA methylation.International journal of legal medicine · 2025Article
- Uncovering Forensic Evidence: A Path to Age Estimation through DNA Methylation.International journal of molecular sciences · 2024Review
- Loss of the Y Chromosome: A Review of Molecular Mechanisms, Age Inference, and Implications for Men's Health.International journal of molecular sciences · 2024Review
- Evaluation of DNAmAge in paired fresh, frozen, and formalin-fixed paraffin-embedded heart tissues.PloS one · 2024Article
- Prediction of chronological age and its applications in forensic casework: methods, current practices, and future perspectives.Forensic sciences research · 2023Review
- A new blood based epigenetic age predictor for adolescents and young adults.Scientific reports · 2023Article
- Article
- A cautionary note on altered pace of aging in the COVID-19 era.Forensic science international. Genetics · 2022Article
- Altered DNA methylation at age-associated CpG sites in children with growth disorders: impact on age estimation?International journal of legal medicine · 2022Article
- Evidence for differences in DNA methylation between Germans and Japanese.International journal of legal medicine · 2022Article
- Analysis ofBiomolecules · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
There is a growing perception that DNA methylation may be influenced by exogenous and endogenous parameters. Knowledge of these factors is of great relevance for the interpretation of DNA-methylation data for the estimation of chronological age in forensic casework. We performed a literature review to identify parameters, which might be of relevance for the prediction of chronological age based on DNA methylation. The quality of age predictions might particularly be influenced by lifetime adversities (chronic stress, trauma/post-traumatic stress disorder (PTSD), violence, low socioeconomic status/education), cancer, obesity and related diseases, infectious diseases (especially HIV and Cytomegalovirus (CMV) infections), sex, ethnicity and exposure to toxins (alcohol, smoking, air pollution, pesticides). Such factors may alter the DNA methylation pattern and may explain the partly high deviations between epigenetic age and chronological age in single cases (despite of low mean absolute deviations) that can also be observed with "epigenetic clocks" comprising a high number of CpG sites. So far, only few publications dealing with forensic age estimation address these confounding factors. Future research should focus on the identification of further relevant confounding factors and the development of models that are "robust" against the influence of such biological factors by systematic investigations under targeted inclusion of diverse and defined cohorts.
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