ArticleMammalian genome : official journal of the International Mammalian Genome Society2020
A scan for genes associated with cancer mortality and longevity in pedigree dog breeds.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Every Tumour Counts: A Comprehensive Overview of Canine Oncology in Portugal.Animals : an open access journal from MDPI · 2025Article
- The effect of body size and inbreeding on cancer mortality in breeds of the domestic dog: a test of the multi-stage model of carcinogenesis.Royal Society open science · 2024Article
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- Selection signature analyses and genome-wide association reveal genomic hotspot regions that reflect differences between breeds of horse with contrasting risk of degenerative suspensory ligament desmitis.G3 (Bethesda, Md.) · 2022Article
- DNA methylation clocks for dogs and humans.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Four novel genes associated with longevity found in Cane corso purebred dogs.BMC veterinary research · 2022Article
- Across-breed genetic investigation of canine hip dysplasia, elbow dysplasia, and anterior cruciate ligament rupture using whole-genome sequencing.Frontiers in genetics · 2022Article
- Comparative Analysis of Mammal Genomes Unveils Key Genomic Variability for Human Life Span.Molecular biology and evolution · 2021Article
- Dog breeds and body conformations with predisposition to osteosarcoma in the UK: a case-control study.Canine medicine and genetics · 2021Article
- Healthy, Active Aging for People and Dogs.Frontiers in veterinary science · 2021Review
- Changes in diet and supplement use in dogs with cancer.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Selective breeding of the domestic dog (Canis lupus familiaris) rigidly retains desirable features, and could inadvertently fix disease-causing variants within a breed. We combine phenotypic data from > 72,000 dogs with a large genotypic dataset to search for genes associated with cancer mortality and longevity in pedigree dog breeds. We validated previous findings that breeds with higher average body weight have higher cancer mortality rates and lower life expectancy. We identified a significant positive correlation between life span and cancer mortality residuals corrected for body weight, implying that long-lived breeds die more frequently from cancer compared to short-lived breeds. We replicated a number of known genetic associations with body weight (IGF1, GHR, CD36, SMAD2 and IGF2BP2). Subsequently, we identified five genetic variants in known cancer-related genes (located within SIPA1, ADCY7 and ARNT2) that could be associated with cancer mortality residuals corrected for confounding factors. One putative genetic variant was marginally significantly associated with longevity residuals that had been corrected for the effects of body weight; this genetic variant is located within PRDX1, a peroxiredoxin that belongs to an emerging class of pro-longevity associated genes. This research should be considered as an exploratory analysis to uncover associations between genes and longevity/cancer mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.