Evidence map›Paper›PMID 32661515›Full record

ArticleBJUI compass2020

Effect of microsurgical varicocelectomy on semen parameters, serum, and intratesticular testosterone levels.

Thiago Fernandes Negris Lima, Fabio Stefano Frech, Premal Patel, Ruben Blachman-Braun, Ranjith Ramasamy

Open access · goldAbstract read
In one paragraph

Article in BJUI compass, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  7. Review
  8. Recent Advances in Treatment of Recurrent Spontaneous Abortion.Obstetrical & gynecological survey · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Thiago Fernandes Negris LimaDepartment of Urology, Miller School of Medicine, University of Miami, Miami, FL, USA.ORCID 0000-0002-7410-7025
Fabio Stefano FrechDepartment of Urology, Miller School of Medicine, University of Miami, Miami, FL, USA.ORCID 0000-0002-0689-6464
Premal PatelDepartment of Urology, University of Manitoba, Winnipeg, MB, Canada.ORCID 0000-0002-2748-6720
Ruben Blachman-BraunDepartment of Urology, Miller School of Medicine, University of Miami, Miami, FL, USA.ORCID 0000-0001-9700-0805
Ranjith RamasamyDepartment of Urology, Miller School of Medicine, University of Miami, Miami, FL, USA.ORCID 0000-0003-1387-7904
University of Miami · USUniversity of Manitoba · CA

Funding

Miami Clinical and Translational Science InstituteUL1TR002736 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN, KOBETZ, ERIN N · 2018 to 2022
$23.2M
NCATS NIH HHS UL1 TR002736
6 · The paper itself

Abstract

objectiveThe goal of this work was to evaluate if men who underwent microsurgical varicocelectomy would have improvement in serum testosterone (T) as well as serum 17-hydroxyprogesterone (17-OHP-An intratesticular T biomarker) in addition to semen parameters after operation. MATERIALS AND

methodsWe conducted a prospective analysis of 30 men who underwent microsurgical varicocelectomy from December 2018 to September 2019. We assessed varicocele grade and laterality, serum T, serum 17-OHP, serum follicle- stimulating hormone (FSH), serum LH, and semen parameters in baseline and follow-up. According to the data distribution, we reported the median and interquartile ranges and utilized the Mann-Whitney U, Student's

resultsIn the baseline, 9 (30%) men had 17-OHP < 55 ng/dL and 21 (70%) men presented with 17-OHP > 55 ng/dL. Also, 19 men had TMSC < 9 million, including 6 men with azoospermia, 1 man with cryptozoospermia, and 11 men with TMSC > 9 million. We found an improvement in most SA parameters of most men, which include concentration (63.3%, 19/30), motility (46.6%, 14/30), and TMSC (60%, 18/30). About seven (36.8%) men had TMSC upgraded to > 9. There was a significant change in volume (2.1 [1.5-2.8] to 2.4 [1.7-3.6] cc,

conclusionDespite improvement in semen parameters following varicocelectomy, we did not see changes in either serum or intratesticular T. This suggests that improvement of semen parameters following varicocele repair could be from factors other than changes in androgen levels within the testis.

Indexed as

17-hydroxyprogesteroneintratesticular testosteronesemen analysistestosteronevaricocele

Identifiers

PMID32661515
PMCPMC7357880
OpenAlexW3023198825

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.