Evidence map›Paper›PMID 32661501›Full record

ArticleAdvanced materials technologies2020

Isotopically Encoded Nanotags for Multiplexed Ion Beam Imaging.

Stefan Harmsen, Ahmet F Coskun, Shambavi Ganesh, Garry P Nolan, Sanjiv S Gambhir

Open access · greenAbstract read
In one paragraph

Article in Advanced materials technologies, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Stefan HarmsenDepartment of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Ahmet F CoskunDepartment of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Shambavi GaneshWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.
Garry P NolanDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Sanjiv S GambhirDepartment of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Stanford University · USGeorgia Institute of Technology · US

Funding

Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5M
Nano Characterization and Nano Fabrication CoreU54CA199075 · NCI · STANFORD UNIVERSITY · PI GAMBHIR, SANJIV S · 2015 to 2019
$9.6M
Raman Molecular Imaging for Early Detection of Colon CancerR01CA182043 · NCI · STANFORD UNIVERSITY · PI CONTAG, CHRISTOPHER H · 2015 to 2020
$2.8M
Spatial Epigenomic Profiling of Immune Cell Signatures at Subcellular Resolution in Health and DiseaseK25AI140783 · NIAID · STANFORD UNIVERSITY · PI COSKUN, AHMET F. · 2018 to 2022
$539k
NCI NIH HHS R01 CA182043NCI NIH HHS U54 CA199075NIAID NIH HHS K25 AI140783NIAID NIH HHS U19 AI057229
6 · The paper itself

Abstract

High-dimensional profiling of markers and analytes using approaches, such as barcoded fluorescent imaging with repeated labeling and mass cytometry has allowed visualization of biological processes at the single-cell level. To address limitations of sensitivity and mass-channel capacity, a nanobarcoding platform is developed for multiplexed ion beam imaging (MIBI) using secondary ion beam spectrometry that utilizes fabricated isotopically encoded nanotags. Use of combinatorial isotope distributions in 100 nm sized nanotags expands the labeling palette to overcome the spectral bounds of mass channels. As a proof-of-principle, a four-digit (i.e., 0001-1111) barcoding scheme is demonstrated to detect 16 variants of

Indexed as

barcodesisotopeslabelsmultiplexed ion beam imagingsilica nanoparticles

Identifiers

PMID32661501
PMCPMC7357881
OpenAlexW3020972568

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.