Evidence map›Paper›PMID 32661395›Full record

ArticleNature neuroscience2020

Regulation of autism-relevant behaviors by cerebellar-prefrontal cortical circuits.

Elyza Kelly, Fantao Meng, Hirofumi Fujita, Felipe Morgado, Yasaman Kazemi, Laura C Rice, Chongyu Ren, Christine Ochoa Escamilla, Jennifer M Gibson, Sanaz Sajadi and 21 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 174 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
174citing papers in PubMed, 1 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

174 citing papers in PubMed, 1 synthesis or guideline pooled it, 270 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Altered Brain Structure in an ATRX-Deficient Mouse Model of Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2026
    Article

114 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 16 institutions in 5 countries.

Elyza KellyDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Fantao MengDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Hirofumi FujitaDepartments of Otolaryngology-Head and Neck Surgery, Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-9630-2756
Felipe MorgadoDepartment of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Yasaman KazemiDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Laura C RiceDepartment of Neuroscience, Center for Behavioral Neuroscience, American University, Washington, DC, USA.
Chongyu RenDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Christine Ochoa EscamillaDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jennifer M GibsonDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Sanaz SajadiDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Robert J PendryDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Tommy TanDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jacob EllegoodMouse Imaging Centre, Toronto Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-1504-3321
M Albert BassonCentre for Craniofacial and Regenerative Biology and MRC Centre for Neurodevelopmental Disorders, King's College London, London, UK.
Randy D BlakelyDepartment of Biomedical Science, Charles E. Schmidt College of Medicine and Brain Institute, Florida Atlantic University, Jupiter, Florida, USA.
Scott V DindotDepartment of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, USA.
Christelle GolzioInstitut de Génétique et de Biologie Moléculaire et Cellulaire; Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale; Université de Strasbourg, Illkirch, France.
Maureen K HahnDepartment of Biomedical Science, Charles E. Schmidt College of Medicine and Brain Institute, Florida Atlantic University, Jupiter, Florida, USA.
Nicholas KatsanisACT-GeM, Department of Human Genetics at Stanley Manne Children's Research Institute; Department of Pediatrics and Cellular and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Diane M RobinsDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA.
Jill L SilvermanMIND Institute and Department of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0001-9357-5476
Karun K SinghDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.
Rachel WevrickDepartment of Medical Genetics, University of Alberta, Edmonton, AB, Canada.ORCID http://orcid.org/0000-0002-3343-5794
Margot J TaylorDepartment of Medical Imaging and Psychology, University of Toronto; Diagnostic Imaging, Hospital for Sick Children, Toronto, ON, USA.
Christopher HammillMouse Imaging Centre, Toronto Hospital for Sick Children, Toronto, ON, Canada.
Evdokia AnagnostouDepartment of Pediatrics, University of Toronto, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, USA.
Brad E PfeifferDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Catherine J StoodleyDepartment of Neuroscience, Center for Behavioral Neuroscience, American University, Washington, DC, USA.ORCID http://orcid.org/0000-0003-2629-0213
Jason P LerchDepartment of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Sascha du LacDepartments of Otolaryngology-Head and Neck Surgery, Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Peter T TsaiDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA. peter.tsai@utsouthwestern.edu.ORCID http://orcid.org/0000-0002-0729-9688
The University of Texas Southwestern Medical Center · USUniversity of Toronto · CAAmerican University · USFlorida Atlantic University · USHospital for Sick Children · CAJohns Hopkins University · USCentre National de la Recherche Scientifique · FRHolland Bloorview Kids Rehabilitation Hospital · CAKing's College London · GBMcMaster University · CANorthwestern University · USSouthwestern Medical Center · USTexas A&M University · USUniversity of Alberta · CAUniversity of California, Davis · USUniversity of Michigan · US

Funding

Project 3P50MH094268 · NIMH · JOHNS HOPKINS UNIVERSITY · PI LEEK, JEFFREY T. · 2011 to 2020
$19.9M
Cerebellar-Cerebro Cortical Circuits in Social BehaviorsR01MH116882 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI Peter T. Tsai · 2019 to 2026
$5.0M
Cerebellar Output CircuitsR01NS105039 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DU LAC, SASCHA · 2018 to 2022
$1.9M
Phenotypic Characterization of Novel Models of Dup15q SyndromeR01NS097808 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SILVERMAN, JILL LYNN · 2017 to 2021
$1.7M
Mechanisms underlying the Cerebellar Contribution to Autism in Mouse Models of Tuberous Sclerosis ComplexK08NS083733 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI TSAI, PETER T. · 2013 to 2017
$952k
Circuit and Molecular Anaylses of Cerebellar Output NeuronsR21NS095232 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DU LAC, SASCHA · 2015 to 2016
$446k
Cerebellum and autism: Neural mechanisms and modulation of predictive processingR15MH106957 · NIMH · AMERICAN UNIVERSITY · PI STOODLEY, CATHERINE J. · 2015 to 2015
$403k
Investigating the cerebellar circuit substrate for modulating ASD core diagnostic behaviorsF31NS107004 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI KELLY, ELYZA · 2018 to 2020
$65k
CIHRMedical Research Council MR/K022377/1Medical Research Council MR/N026063/1NIMH NIH HHS P50 MH094268NIMH NIH HHS R01 MH116882NIMH NIH HHS R15 MH106957NINDS NIH HHS F31 NS107004NINDS NIH HHS K08 NS083733NINDS NIH HHS R01 NS097808NINDS NIH HHS R01 NS105039NINDS NIH HHS R21 NS095232
6 · The paper itself

Abstract

Cerebellar dysfunction has been demonstrated in autism spectrum disorders (ASDs); however, the circuits underlying cerebellar contributions to ASD-relevant behaviors remain unknown. In this study, we demonstrated functional connectivity between the cerebellum and the medial prefrontal cortex (mPFC) in mice; showed that the mPFC mediates cerebellum-regulated social and repetitive/inflexible behaviors; and showed disruptions in connectivity between these regions in multiple mouse models of ASD-linked genes and in individuals with ASD. We delineated a circuit from cerebellar cortical areas Right crus 1 (Rcrus1) and posterior vermis through the cerebellar nuclei and ventromedial thalamus and culminating in the mPFC. Modulation of this circuit induced social deficits and repetitive behaviors, whereas activation of Purkinje cells (PCs) in Rcrus1 and posterior vermis improved social preference impairments and repetitive/inflexible behaviors, respectively, in male PC-Tsc1 mutant mice. These data raise the possibility that these circuits might provide neuromodulatory targets for the treatment of ASD.

Indexed as

AnimalsAutism Spectrum DisorderCerebellumMaleMiceMice, Mutant StrainsNeural PathwaysPrefrontal Cortex

Identifiers

PMID32661395
PMCPMC7483861
OpenAlexW3041250095

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.